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Mechanism and medical implications of mammalian autophagy

Nature Reviews Molecular Cell Biology, 2018
Ivan Đikić, Zvulun Elazar
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The mechanisms and roles of selective autophagy in mammals

Nature Reviews Molecular Cell Biology, 2022
J. N. S. Vargas   +4 more
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Imaging Autophagy

Current Protocols in Cytometry, 2014
AbstractAutophagy is a membrane‐trafficking pathway activated to deliver cytosolic material for degradation to lysosomes through a novel membrane compartment, the autophagosome. Fluorescence microscopy is the most common method used to visualize proteins inside cells, and it is widely used in the autophagy field.
Eleftherios, Karanasios   +3 more
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Autophagy

1996
Autophagy or autophagocytosis are terms given to a membrane-mediated process in eukaryotic cells in which portions of cytoplasm are sequestered within vacuoles and degraded by acid hydrolases that are acquired by fusion with lysosomes. Although vacuoles of this type may be formed under pathologic conditions, autophagy is fundamentally a physiologic ...
MORTIMORE G. E.   +3 more
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Autophagy

Annals of the New York Academy of Sciences, 2006
Abstract: Autophagy is a major intracellular pathway for the degradation and recycling of long‐lived proteins and cytoplasmic organelles. Like apoptotic programmed cell death, autophagy is an essential part of growth regulation and maintenance of homeostasis in multicellular organisms.
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Selective autophagy

Essays in Biochemistry, 2013
During the last decade it has become evident that autophagy is not simply a non-selective bulk degradation pathway for intracellular components. On the contrary, the discovery and characterization of autophagy receptors which target specific cargo for lysosomal degradation by interaction with ATG8 (autophagy-related protein 8)/LC3 (light-chain 3) has ...
Steingrim, Svenning, Terje, Johansen
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Autophagy inhibitors

Cellular and Molecular Life Sciences, 2015
Autophagy is a lysosome-dependent mechanism of intracellular degradation. The cellular and molecular mechanisms underlying this process are highly complex and involve multiple proteins, including the kinases ULK1 and Vps34. The main function of autophagy is the maintenance of cell survival when modifications occur in the cellular environment.
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