Results 31 to 40 of about 197,120 (261)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
The impact of autopsy participation on clinical residency
Journal of General and Family Medicine, 2021 Background Autopsy has had an essential role in ensuring the quality of education and medical care. However, its role in clinical residency has not been clarified.
Kohta Katayama +7 more
doaj +1 more source
Autopsy in a Neonatal Intensive Care Unit: pathological and clinical agreement
Jornal de Pediatria, 2022 Objectives: To evaluate neonatal autopsy rates at a tertiary hospital in southern Brazil ascertain the level of agreement between premortem and postmortem diagnosis. Methods: The authors reviewed all neonatal autopsies performed over a 10-year period and
Camila Penso +7 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
The evolution of minimally invasive tissue sampling in postmortem examination: a narrative review
Global Health Action, 2020 Background Because of low acceptance rates and limited capacity, complete diagnostic autopsies (CDAs) are seldom conducted in low- and middle-income countries (LMICs).
Christina R. Paganelli +8 more
doaj +1 more source
Leukemia, 2014 Staining with annexin V, which detects the externalization of phosphatidylserine on cells, is a widespread method for the assessment of cell death, and in particular, apoptosis.1 Although additional assays are important for demonstrating apoptosis, many studies use annexin V staining in isolation and directly equate annexin V positivity with apoptosis.
Bendall, L J, Green, D R
openaire +2 more sources
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Egyptian Journal of Forensic SciencesBackground Myocardial bridging (MB) is a congenital coronary anomaly characterized by a segment of coronary artery passing an intramuscular course through the myocardium.
Emre Nuri İgde +4 more
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source