Results 61 to 70 of about 403,030 (353)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Report and Recommendations of the Association of Pathology Chairs’ Autopsy Working Group

open access: yesAcademic Pathology, 2018
Autopsy has been a foundation of pathology training for many years, but hospital autopsy rates are notoriously low. At the 2014 meeting of the Association of Pathology Chairs, some pathologists suggested removing autopsy from the training curriculum of ...
Gregory G. Davis MD, MSPH   +13 more
doaj   +1 more source

PSYCHOLOGICAL AUTOPSIES [PDF]

open access: yes, 2000
From time to time incidents of suspicious death occur in which the mental state of a deceased person needs to be assessed. If some evaluation can be made of the sort of person they were, their personality and thought processes, especially as that may throw light on any involvement they themselves had in their death, then it may assist the investigation
openaire   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Molecular Genetic Characteristics of Mycobacterium tuberculosis Isolates from Patients with HIV-Associated Tuberculosis

open access: yesТуберкулез и болезни лёгких
The objective: to provide molecular genetic characteristics of Mycobacterium tuberculosis isolates from patients with HIV-associated tuberculosis.Subjects and Methods. Two groups of M.
A. A. Gerasimova   +4 more
doaj   +1 more source

Nonischemic left ventricular scar and cardiac sudden death in the young [PDF]

open access: yes, 2016
Nonischemic Left Ventricular Scar (NLVS) is a pattern of myocardial injury characterized by midventricular and/or subepicardial gadolinium hyper enhancement at cardiac magnetic resonance, in absence of significant coronary artery disease.
CERBELLI, BRUNA   +10 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

THE AIDS PATIENT SUFFERING FROM GENERALIZED MYCOBACTERIOSIS

open access: yesТуберкулез и болезни лёгких, 2015
The clinical case of mycobacteriosis caused by drug resistant strains of M. avium (subspecies of hominissuis), was observed in the patient su}ering from HIV at the stage of AIDS.
T. F. Otten   +4 more
doaj  

Medicolegal autopsy administration

open access: yesMedicine Science, 2018
The term autopsy which means “seeing with one’s own eyes” origins from the words ‘’auto’’ and ‘’opsis’’. There are two types of autopsy as medical and forensic autopsies.
Zeynep Yener
doaj   +1 more source

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