Heart Rhythm O2Background: Autopsy, the gold standard for determining the cause of death, is declining globally. Significant differences exist between clinical diagnoses and those revealed at autopsy.
Dean M. Nelson, BBiomed, MD +8 more
doaj +1 more source
Inhibition of Classical and Alternative Complement Pathway by Ravulizumab and Eculizumab
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To explore the feasibility of classical (CH50) and alternative (AH50) complement pathway activity as potential biomarkers for treatment guidance and monitoring during therapy with ravulizumab in patients with generalized myasthenia gravis (gMG) and compare these to therapeutic drug monitoring under eculizumab.
Lea Gerischer +14 more
wiley +1 more source
Barriers to Creutzfeldt-Jakob Disease Autopsies, California
Emerging Infectious Diseases, 2004 Creutzfeldt-Jakob disease (CJD) surveillance relies on autopsy and neuropathologic evaluation. The 1990–2000 CJD autopsy rate in California was 21%. Most neurologists were comfortable diagnosing CJD (83%), but few pathologists felt comfortable diagnosing
Janice K. Louie +6 more
doaj +1 more source
Unravelling the mystery behind sudden death in the young: a wake up call for nationwide autopsy-based approach [PDF]
, 2017 Gherardo Finocchiaro +2 more
openalex +1 more source
Chronological and Spatial Distribution of Skeletal Muscle Fat Replacement in FHL1‐Related Myopathies
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives Variants in the FHL1 gene cause FHL1‐related myopathies (FHL1‐RMs), a group of neuromuscular disorders with diverse clinical presentations. This study aimed to comprehensively characterize the spatial and temporal patterns of skeletal muscle fat replacement throughout the whole body in FHL1‐RMs, to examine disease progression over ...
Rui Shimazaki +8 more
wiley +1 more source
Case report of a Japanese patient with chronic renal failure who developed
, 2022 Yoshifumi Amari +6 more
openalex +1 more source
Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky +8 more
wiley +1 more source
Affinities and densities of high-affinity [3H]muscimol (GABA-A) binding sites and of central benzodiazepine receptors are unchanged in autopsied brain tissue from cirrhotic patients with hepatic encephalopathy [PDF]
, 1988 Roger F. Butterworth +3 more
openalex +1 more source
Leigh syndrome in an infant: autopsy and histopathology findings [PDF]
, 2021 Arushi Gahlot Saini +4 more
openalex +1 more source
, 2000 From time to time incidents of suspicious death occur in which the mental state of a deceased person needs to be assessed. If some evaluation can be made of the sort of person they were, their personality and thought processes, especially as that may throw light on any involvement they themselves had in their death, then it may assist the investigation
openaire +1 more source