Results 21 to 30 of about 97,748 (326)

Antitoxin CrlA of CrlTA Toxin–Antitoxin System in a Clinical Isolate Pseudomonas aeruginosa Inhibits Lytic Phage Infection

Frontiers in Microbiology, 2022
Pseudomonas aeruginosa is an important opportunistic pathogen in cystic fibrosis patients and immunocompromised individuals, and the toxin–antitoxin (TA) system is involved in bacterial virulence and phage resistance.
Muyang Ni, Jianzhong Lin, Jianzhong Lin, Jiayu Gu, Jiayu Gu, Shituan Lin, Shituan Lin, Mei He, Yunxue Guo, Yunxue Guo, Yunxue Guo   +10 more
doaj   +1 more source

Fixed Compared With Autoregulation-Oriented Blood Pressure Thresholds After Mechanical Thrombectomy for Ischemic Stroke

Stroke, 2020
Supplemental Digital Content is available in the text. Background and Purpose— Loss of cerebral autoregulation in the acute phase of ischemic stroke leaves patients vulnerable to blood pressure (BP) changes.
N. Petersen, Andrew Silverman, S. Strander, Sreeja Kodali, Anson Wang, L. Sansing, J. Schindler, G. Falcone, E. Gilmore, Adam S. Jasne, B. Cord, R. Hebert, Michele H Johnson, C. Matouk, K. Sheth   +14 more
semanticscholar   +1 more source

Vagolytic atropine attenuates cerebral vasodilation response during acute orthostatic hypotension [PDF]

Korean Journal of Anesthesiology, 2015
BackgroundAtropine is an anticholinergic drug which is commonly used in clinical practice. The effect of parasympathetic block with atropine on dynamic cerebrovascular regulation remains unclear.
Woo-Jong Choi, Kichang Lee, Young-Kug Kim, Kyo-Joon Song, Sung-Moon Jeong, Gyu-Sam Hwang   +5 more
doaj   +1 more source

Vascular Reactivity to Hypercapnia Is Impaired in the Cerebral and Retinal Vasculature in the Acute Phase After Experimental Subarachnoid Hemorrhage

Frontiers in Neurology, 2022
Objective: Impaired cerebral blood flow (CBF) regulation, such as reduced reactivity to hypercapnia, contributes to the pathophysiology after aneurysmal subarachnoid hemorrhage (SAH), but temporal dynamics in the acute phase are unknown.
Laura Warner, Annika Bach-Hagemann, Walid Albanna, Hans Clusmann, Gerrit A. Schubert, Gerrit A. Schubert, Ute Lindauer, Ute Lindauer, Catharina Conzen-Dilger   +8 more
doaj   +1 more source

FUS ALS-causative mutations impair FUS autoregulation and splicing factor networks through intron retention

Nucleic Acids Research, 2020
Mutations in the RNA-binding protein FUS cause amyotrophic lateral sclerosis (ALS), a devastating neurodegenerative disease. FUS plays a role in numerous aspects of RNA metabolism, including mRNA splicing.
J. Humphrey, N. Birsa, Carmelo Milioto, Martha McLaughlin, A. Ule, D. Robaldo, A. B. Eberle, Rahel Kräuchi, Matthew Bentham, Anna L. Brown, Seth Jarvis, C. Bodo, M. G. Garone, A. Devoy, G. Soraru', A. Rosa, I. Bozzoni, E. Fisher, O. Mühlemann, G. Schiavo, M. Ruepp, A. Isaacs, V. Plagnol, P. Fratta   +23 more
semanticscholar   +1 more source

Timing is everything: Exercise therapy and remote ischemic conditioning for acute ischemic stroke patients

Brain Circulation, 2021
Physical exercise is a promising rehabilitative strategy for acute ischemic stroke. Preclinical trials suggest that exercise restores cerebral blood circulation and re-establishes the blood–brain barrier's integrity with neurological function and motor ...
Hangil Lee, Ho Jun Yun, Yuchuan Ding
doaj   +1 more source

Coupling metabolic addiction with negative autoregulation to improve strain stability and pathway yield

bioRxiv, 2020
Metabolic addiction, an organism that is metabolically addicted with a compound to maintain its growth fitness, is an underexplored area in metabolic engineering.
Yongkun Lv, Yang Gu, Jingliang Xu, Jingwen Zhou, Peng Xu   +4 more
semanticscholar   +1 more source

Transcriptional autoregulation in development [PDF]

Current Biology, 2009
The authors would like to thank Peter Harte and Mark Ptashne for helpful and stimulating comments on the manuscript. Our lab's research is supported by grants from the NIH and NSF. The UNC Developmental Biology NIH training grant provided support to J.C.P.
Joseph C. Pearson, Stephen T. Crews
openaire   +3 more sources

FOXC2 Autoregulates Its Expression in the Pulmonary Endothelium After Endotoxin Stimulation in a Histone Acetylation-Dependent Manner

Frontiers in Cell and Developmental Biology, 2021
The innate immune response of pulmonary endothelial cells (EC) to lipopolysaccharide (LPS) induces Forkhead box protein C2 (FOXC2) activation through Toll Like Receptor 4 (TLR4).
Sheng Xia, Wei Yu, Heather Menden, Scott T. Younger, Venkatesh Sampath   +4 more
doaj   +1 more source

Temporal Course of Cerebral Autoregulation in Patients With Narcolepsy Type 1: Two Case Reports

Frontiers in Neurology, 2019
Cerebral autoregulation is the mechanism by which constant cerebral blood flow is maintained despite changes in arterial blood pressure. In the two presented cases, cerebral autoregulation was impaired in patients with narcolepsy type 1, and both ...
Zhen-Ni Guo, Xin Sun, Yingkai Zhao, Xiuli Yan, Ran Zhang, Zan Wang, Yi Yang, Yi Yang   +7 more
doaj   +1 more source