Results 181 to 190 of about 6,262,677 (213)

Pregnancy in Autosomal Dominant Polycystic Kidney Disease

Advances in Kidney Disease and Health, 2023
Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disorder occurring in approximately 1:1000 individuals. ADPKD is characterized by gradual cyst expansion and kidney enlargement and is a slowly progressive disorder where patients typically initiate renal replacement therapy in the sixth decade of life.
Mina, Al Sayyab, Arlene, Chapman
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Hypertension in autosomal dominant polycystic kidney disease

Current Opinion in Nephrology and Hypertension, 1995
Hypertension occurs frequently in autosomal dominant polycystic kidney disease. Increased activity of the renin-angiotensin system contributes to the development and maintenance of hypertension before the development of renal failure. Angiotensin-converting enzyme inhibitors are indicated for treatment of hypertension before the development of renal ...
P S, Parfrey, B J, Barrett
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Rationale and Design of the TEMPO (Tolvaptan Efficacy and Safety in Management of Autosomal Dominant Polycystic Kidney Disease and Its Outcomes) 3-4 Study

American Journal of Kidney Diseases, 2011
Current management of autosomal dominant polycystic kidney disease (ADPKD) is focused on treating disease complications, not on slowing cyst development or preventing progression to kidney failure.
Esther Meijer, Ron T Gansevoort, Ronald D Perrone   +2 more
exaly   +2 more sources

Autosomal dominant polycystic kidney disease

BMJ, 2016
#### What you need to know Polycystic kidney disease (PKD) is an inherited condition defined by the pathological development of fluid-filled cysts throughout the kidneys leading to organ enlargement (fig 1⇓) and chronic kidney disease. Autosomal dominant polycystic kidney disease (ADPKD) is the commonest inherited kidney disease1 and is the fourth ...
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Autosomal Dominant Polycystic Kidney Disease

New England Journal of Medicine, 1990
Autosomal dominant polycystic kidney disease (ADPKD) is a hereditary disease occurring in 1 in 200 to 1 in 1,000 individuals. ADPKD is characterized by cystic lesions in the kidneys and often by structural abnormalities in the gastrointestinal tract and cardiovascular system.
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Nephrolithiasis in Autosomal Dominant Polycystic Kidney Disease

Journal of Endourology, 2010
Autosomal dominant polycystic kidney disease (ADPKD) manifests with renal and extrarenal abnormalities and is inherited in an autosomal dominant fashion. In addition to multiple renal cysts, abnormalities such as liver cysts (80%), pancreatic cysts, splenic cysts, pulmonary cysts, berry aneurysms in the distribution of arterial circle of Willis (8 ...
Uwais B, Mufti, Sarath K, Nalagatla
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Angiogenesis and autosomal dominant polycystic kidney disease

Pediatric Nephrology, 2012
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the growth of multiple cysts that in many cases result in end-stage renal disease. Current strategies to reduce cyst progression in ADPKD focus on modulating cell turnover, fluid secretion, and vasopressin signalling; but an alternative approach may be to target pathways providing
Huang, JL, Woolf, AS; id_orcid 0000-0001-5541-1358, Long, DA   +2 more
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MRI in autosomal dominant polycystic kidney disease

Journal of Magnetic Resonance Imaging, 2019
Magnetic resonance imaging (MRI) is increasingly used in autosomal dominant polycystic kidney disease (ADPKD) for diagnosis, classification, assessment of disease progression and treatment response, and for identifying complications. Herein we review the role of MRI in the management of patients with ADPKD.
Weiguo Zhang, Jon D. Blumenfeld, Martin R. Prince   +2 more
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Epigenetics in autosomal dominant polycystic kidney disease

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Autosomal dominant polycystic kidney disease (ADPKD) is the fourth leading cause of end-stage renal disease, contributing substantially to patient morbidity, mortality, and healthcare system strain. Emerging research highlights a pivotal role of epigenetics in ADPKD's pathophysiology, where mechanisms like DNA methylation, histone modifications, and ...
Zhipeng, Yan, Feng, Cao, Tingting, Shao, Bingqing, Liao, Guoping, Wang, Xianhu, Tang, Hongwen, Luo, Fengjuan, Zhu, Yunqiang, Liao, Fengxia, Zhang, Xiaosheng, Li, Jian, Wang, Zhenzhen, Liu, Shougang, Zhuang   +13 more
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Tolvaptan and Autosomal Dominant Polycystic Kidney Disease

New England Journal of Medicine, 2017
Approximately half the patients with autosomal dominant polycystic kidney disease (ADPKD), a condition due to deficiency in polycystin 1 or 2, have end-stage kidney disease by 60 years of age.1,2 Once progression begins, the mean decline in the estimated glomerular filtration rate (GFR) is approximately 4 to 6 ml per minute per 1.73 m2 of body-surface ...
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