Results 51 to 60 of about 6,262,677 (213)
Metabolism-based approaches for autosomal dominant polycystic kidney disease
Frontiers in Molecular Biosciences, 2023 Autosomal Dominant Polycystic Kidney Disease (ADPKD) leads to end stage kidney disease (ESKD) through the development and expansion of multiple cysts throughout the kidney parenchyma.
Ivona Bakaj, Alessandro Pocai
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Organoids: Current Applications and Future Directions
MedComm, Volume 7, Issue 10, October 2026.Organoids are three‐dimensional multicellular structures derived from stem cells or primary tissues that recapitulate key structural and functional features of native organs. Advances in stem cell biology, biomaterials, and bioengineering have established organoids as powerful platforms for studying human development and disease mechanisms, drug ...
Yueqi Leng +14 more
wiley +1 more source
Iron and Other Metal Ions in Human Health and Disease
MedComm, Volume 7, Issue 10, October 2026.Iron, copper, zinc, and calcium orchestrate cellular function through distinct yet cooperative mechanisms: redox‐active iron and copper cycle between oxidation states to act as Fenton catalysts and electron carriers in oxidative phosphorylation (OXPHOS); redox‐inert zinc serves as a structural component of zinc‐finger proteins and a catalytic cofactor ...
Xiaofeng Dai, Jitian Li
wiley +1 more source
Autosomal Dominant Polycystic Kidney Disease Induced by Ciliary Defects
, 2015 Autosomal dominant polycystic kidney disease (ADPKD) is a common genetic renal disease, which is caused by pathogenic mutations of either PKD1 (85%) or PKD2 (15%) genes, encoding for polycystin-1 (PC1) or polycystin-2 (PC2), respectively.
core +1 more source
Renal cysts in children: a single centre study
Pediatria i Medycyna Rodzinna, 2018 Kidney cysts may be congenital (associated or not with genetic disorders) or rarely acquired. They may be an isolated abnormality or be part of an anomaly syndrome.
Anna Medyńska +5 more
doaj +1 more source
Renal cell carcinoma in autosomal dominant polycystic kidney disease: A case report
Radiology Case Reports, 2023 Autosomal dominant polycystic kidney disease (ADPKD) is one of the congenital cystic renal diseases with the highest incidence. ADPKD was suspected of being a risk factor for the emergence of RCC.
Gullyawan Rooseno +3 more
doaj +1 more source
MedComm, Volume 7, Issue 10, October 2026.The Hippo–YAP/TAZ–TEAD pathway integrates mechanical and biochemical cues to govern organ growth, regeneration, cancer, and fibrosis. This review dissects pathway physiology, TEAD structural pharmacology and ligandable pockets, and therapeutic strategies spanning palmitoylation‐pocket inhibitors, PROTAC degraders, and gene/RNA therapies, highlighting ...
Xiaodan Qu, Zhan‐you Wang
wiley +1 more source
, 2017 Introduction: The most common hereditary kidney condition is autosomal dominant polycystic kidney disease. It is the cause of 5–10% of end-stage renal disease.
Marcin Tkaczyk +11 more
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Pain in Autosomal Dominant Polycystic Kidney Disease [PDF]
European Medical Journal Nephrology, 2014 Autosomal dominant polycystic kidney disease (ADPKD) is an inherited disorder affecting 1 in 1,000 people and is responsible for 10% of cases of end-stage renal disease.
Mariusz Niemczyk
doaj
AMPK and Polycystic Kidney Disease Drug Development: An Interesting Off-Target Target
Frontiers in Medicine, 2022 Autosomal Dominant Polycystic Kidney Disease is a genetic disease that causes dramatic perturbations of both renal tissue architecture and of a multitude of cellular signaling pathways.
Michael J. Caplan
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