Results 111 to 120 of about 1,238,433 (289)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
EVALUATION OF URETEROSCOPIC PNEUMATIC LITHOTRIPSY FOR URETERAL STONES
Journal of University Medical & Dental College, 2014 : OBJECTIVE: To evaluate success rate, auxiliary procedures and complications associated with ureteroscopic pneumatic lithotripsy of ureteric stones. PATIENTS AND METHODS: The study was conducted among 100 patients between May 2011 to July 2013. The mean
Ihsan Ullah Khan
doaj
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
"Jen mě prosili, abych šel ven a zavolal na Božího syna, aby jim přivedl nějaké tuleně.“ Grónská zkušenost misionářů obnovené Jednoty bratrské v 18. století / "They asked me to call the Son of God who will bring them some seals." The Greenland experience of Herrnhut missionaries in the 18th century [PDF]
Historie - Otázky - Problémy, 2016 The beginning of the 18th century saw a revival of interest in distant Greenland, a possession of the Kingdom of Denmark. The early pioneers were missionaries, first the Danish Lutheran priest Hans Egede and after 1733, members of the renewed Brüder ...
Zdeněk Hojda, Markéta Křížová
doaj
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Linguistica Brunensia, 2016 In this article, we offer support for two claims and one observation. The claims are the following: first, there are EA (external arguments) of different types and these are introduced by different heads. This claim has been made originally for on Salish
Lucie Taraldsen Medová +1 more
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Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source