Results 41 to 50 of about 296,851 (282)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Проект увеличения отпуска теплоты от Северской ТЭЦ [PDF]
, 2016 Реферат Выпускная квалификационная работа стр.,107, рисунков 16, таблиц 22, источников 20, приложения 1, 6 л. графического материала. Ключевые слова: сетевые подогреватели, ТЭЦ, реконструкция и замена оборудования, тепловая и электрическая мощность ...
Семенов, Андрей Валерьевич
core
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
发电技术ObjectivesTo enhance the intelligent management of substation equipment maintenance, timely identify and mitigate the risks of failures caused by device overheating, and ensure the safe and stable operation of the power grid, the temperature situation ...
CHEN Yu +7 more
doaj +1 more source
Methods detection place depressurization of thermal power equipment, operating under vacuum
Известия высших учебных заведений: Проблемы энергетики, 2017 This article considers the urgency of the problem of ensuring impermeability of vacuum system of the turbine and vacuum deaerators. Developed and successfully tested in an industrial operation highly effective instrument and without instruments methods ...
V. I. Sharapov +2 more
doaj +1 more source
Diesel engine catalytic combustor system [PDF]
, 1984 A low compression turbocharged diesel engine is provided in which the turbocharger can be operated independently of the engine to power auxiliary equipment.
Ream, L. W.
core +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source