Results 151 to 160 of about 273,093 (318)

Applications and prospects of artificial intelligence in the auxiliary diagnosis of pediatric pulmonary tuberculosis. [PDF]

Front Microbiol
Lu X, Hu Y, Hu Y, Zhao F, Fan P, Luo Y, Li J.   +6 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Predictive impact of PI-RADS 3 lesion volume/total prostate volume ratio in prostate cancer diagnosis in biopsy-naïve patients. [PDF]

Turk J Med Sci
Özsoy E, Kutluhan MA, Tokuç E, Kayar R, Demir S, Meriç K, Öztürk Mİ.   +6 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Performance of multi-trait and single-trait genomic selection for grain Fe and Zn concentrations in sorghum under different breeding constraints. [PDF]

Sci Rep
Habyarimana E, Chavan S, Hugar C, Suvarna, Thakur NR, Lopez-Cruz M, Li J, Ruperao P.   +7 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

GSBS News, Winter 2001-2002 [PDF]

, 2001
Graduate School of Biomedical Sciences, University of Texas Health Science Center at Houston/M.D. Anderson Cancer Center
core   +1 more source

High-dimensional multiple imputation for partially observed confounders including natural language processing-derived auxiliary covariates. [PDF]

Am J Epidemiol
Weberpals J, Shaw PA, Lin KJ, Wyss R, Plasek JM, Zhou L, Ngan K, DeRamus T, Raman SR, Hammill BG, Lee H, Toh S, Connolly JG, Dandreo KJ, Tian F, Liu W, Li J, Hernández-Muñoz JJ, Schneeweiss S, Desai RJ.   +19 more
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Ярово – стратифицированный комплекс финального раннего палеолита на юго-западе Восточно-Европейской равнины. Вопросы хронологии, таксономии и эволюции галечно-отщепового технокомплекса

Уфимский археологический вестник
В статье публикуются данные о местонахождении раннего палеолита Ярово, обнаруженного в Приднестровье (Молдова) в 1987 г. и исследованном в 1988–89 гг. Работы проводил При­днестровский палеолитический отряд Ленинградского отделения Института археологии АН
Анисюткин Николай Кузьмич
doaj   +1 more source