Results 51 to 60 of about 5,689,842 (310)
Molecular Therapy: Nucleic Acids, 2016 Recent years have seen major breakthroughs in genome-engineering systems, such as transposon-mediated gene delivery systems and CRISPR-Cas9-mediated genome-editing tools.
Riccardo Mezzadra +3 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
, 1920 "Reprint from the Manual of Ceremonies as prepared by National Headquarters, The American Legion Auxiliary.
American Legion. Auxiliary. Department of Kansas.
core +1 more source
Trends and risk factors for infant mortality in the Lao People’s Democratic Republic
Scientific Reports, 2020 A high infant mortality rate (IMR) indicates a failure to meet people’s healthcare needs. The IMR in Lao People’s Democratic Republic has been decreasing but still remains high.
Viengsakhone Louangpradith +6 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
On estimating quantiles using auxiliary information
, 2015 We propose a transformation-based approach for estimating quantiles using auxiliary information. The proposed estimators can be easily implemented using a regression estimator.
Yves G. Berger +3 more
core +1 more source
Challenges in Kazakh auxiliary selection
Proceedings of the International Conference on Head-Driven Phrase Structure Grammar, 2020 This paper proposes an account for the four auxiliaries in Kazakh that express the imperfective aspect. The main factors – the auxiliary, the main verb, their inflections and the aspectual specifications reveal a complicated system, which can be captured with an appropriate monotonic, multiple inheritance type hierarchy using online-type construction ...
openaire +3 more sources
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Evaluating the impact of auxiliary fan practices on localised subsurface ventilation
International Journal of Mining Science and Technology, 2019 Mines are continually expanding in size and depth, leading to an increased reliance on localised subsurface ventilation systems. The use of underground auxiliary fans is a favoured method to increase and control airflow in working areas.
David J. de Villiers +4 more
doaj +1 more source