Results 91 to 100 of about 469,591 (281)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

On some new approaches to practical Slepian-Wolf compression inspired by channel coding [PDF]

, 2006
This paper considers the problem, first introduced by Ahlswede and Körner in 1975, of lossless source coding with coded side information. Specifically, let X and Y be two random variables such that X is desired losslessly at the decoder while Y serves as
Coleman, Todd P., Effros, Michelle, Lee, Anna H., Médard, Muriel   +3 more
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Pitfalls of imputing using incomplete auxiliary variables

American Journal of Epidemiology
We respond to Madley-Dowd et al's recent article in American Journal of Epidemiology. We show that standard imputation algorithms can fail for simple graphs (such as those used in Madley-Dowd et al's simulation study) even when the full data distribution is identified and an appropriate imputation estimator would be straightforward to design.
Maya B Mathur, Ilya Shpitser
openaire   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Optimizing Finite Population Mean Estimation Using Simulation and Empirical Data

Mathematics
Two-phase sampling is an effective sampling approach that is useful in sample surveys when prior auxiliary information is not available. When two variables have an association, the ranks of the auxiliary variable are proportional to the study variable ...
Abdulaziz S. Alghamdi, Fatimah A. Almulhim   +1 more
doaj   +1 more source

Estimation of finite population distribution function with dual use of auxiliary information under non-response.

PLoS ONE, 2020
In this paper, we propose two new families of estimators for estimating the finite population distribution function in the presence of non-response under simple random sampling.
Sardar Hussain, Sohaib Ahmad, Sohail Akhtar, Amara Javed, Uzma Yasmeen   +4 more
doaj   +1 more source

Statistical Inference Based on Randomly Generated Auxiliary Variables [PDF]

Journal of the Royal Statistical Society Series B: Statistical Methodology, 2017
SummaryIn most real life studies, auxiliary variables are available and are employed to explain and understand missing data patterns and to evaluate and control causal relationships with variables of interest. Usually their availability is assumed to be a fact, even if the variables are measured without the objectives of the study in mind. As a result,
openaire   +3 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Auxiliary-variable Exact Hamiltonian Monte Carlo Samplers for Binary Distributions [PDF]

, 2015
We present a new approach to sample from generic binary distributions, based on an exact Hamiltonian Monte Carlo algorithm applied to a piecewise continuous augmentation of the binary distribution of interest.
Pakman, Ari, Paninski, Liam
core