Results 151 to 160 of about 75,557 (304)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Between-Word Assimilation and Syntax in Child Language Development: a Case Study [PDF]

, 2012
Previous developmental research has shown that interactions exist between the emergence of connected speech processes and the acquisition of syntax. This study is the first to have investigated these interactions in detail, using a dense data corpus ...
Bryan, Sarah Catherine
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

A dynamic auxiliary task construction-based evolutionary multitasking algorithm for large-scale multiobjective optimization

Complex & Intelligent Systems
Evolutionary multitask optimization shows great potential in large-scale multiobjective optimization problems (LSMOPs) by facilitating knowledge transfer across reduced spaces (constructed as auxiliary tasks).
Jing Jiang, Pingping Tong, Juanjuan Hong, Zhe Liu, Fei Han, Benyue Su   +5 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Auxiliary Variable Methods for Markov Chain Monte Carlo with Applications

, 1997
Suppose one wishes to sample from the density ß(x) using Markov chain Monte Carlo (MCMC). An auxiliary variable u and its conditional distribution ß(ujx) can be defined, giving the joint distribution ß(x; u) = ß(x)ß(ujx). A MCMC scheme which samples over
David M. Higdon
core  

Random non-response on study variable versus on study as well as auxiliary variables

, 2013
In most practical situations in sample surveys, random non-response, for some units, is present on both the study and auxiliary variables. In other situations, it may be present on study variable only since information on the auxiliary variable may be ...
Tracy, Derric Shannon, Osahan, S. S.
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Mixed Bayesian Networks with Auxiliary Variables for Automatic Speech Recognition [PDF]

Standard hidden Markov models (HMMs), as used in automatic speech recognition (ASR), calculate their emission probabilities by an artificial neural network (ANN) or a Gaussian distribution conditioned on the hidden state variable, considering the ...
Magimai.-Doss, Mathew, Bourlard, Hervé, Stephenson, Todd Andrew   +2 more
core   +1 more source

Optimal strategy for improved estimation of population mean of sensitive variable using non-sensitive auxiliary variable

Journal of Big Data
To improve the transformed ratio type estimators, this study uses new population parameters that are derived from extra information using a randomized response technique (RRT).
Abdullah A. Zaagan, Dinesh K. Sharma, Ali M. Mahnashi, Mutum Zico Meetei, Subhash Kumar Yadav, Aakriti Sharma, Pranav Sharma   +6 more
doaj   +1 more source