Results 31 to 40 of about 539 (92)

Overproduction of 42 Amino Acids Long Amyloid Beta Leads to Activation of Secretory Autophagy and Development of Drusen‐Like Structures Originating From Retinal Pigment Epithelium

The FASEB Journal, Volume 40, Issue 5, 15 March 2026.
The role of 42 amino acids long amyloid beta (Aβ) in the retinal pigment epithelium (RPE) was investigated using 5xFAD mice model overproducing Aβ. The RPE cells of 5xFAD mice showed increased oxidative stress, accumulation of autophagy‐destined proteins, increased expression of secretory autophagy markers, and increase in epithelial‐to‐mesenchymal ...
Johanna Ruuth, Toni Tamminen, Elisa Toropainen, Heikki Tanila, Juha M. T. Hyttinen, Tarja Malm, Kai Kaarniranta, Ali Koskela   +7 more
wiley   +1 more source

Visual Function Assessment in Geographic Atrophy: A Review

Clinical &Experimental Ophthalmology, Volume 54, Issue 2, Page 260-274, March 2026.
ABSTRACT Geographic atrophy (GA) causes significant vision impairment and reduction in vision‐related quality of life. Fundus autofluorescence (FAF) is the gold standard of structural assessment of GA but is a surrogate marker for vision loss, which can be assessed by tests of visual function and functional vision.
Ye Li, Lauren N. Ayton, Adrian T. Fung
wiley   +1 more source

Age-related macular degeneration: suitability of optogenetic therapy for geographic atrophy

Frontiers in Neuroscience
Age-related macular degeneration (AMD) is a growing public health concern given the aging population and it is the leading cause of blindness in developed countries, affecting individuals over the age of 55 years.
Grace A. Borchert, Grace A. Borchert, Hoda Shamsnajafabadi, Benjamin W. J. Ng, Benjamin W. J. Ng, Kanmin Xue, Kanmin Xue, Samantha R. De Silva, Samantha R. De Silva, Susan M. Downes, Susan M. Downes, Robert E. MacLaren, Robert E. MacLaren, Jasmina Cehajic-Kapetanovic, Jasmina Cehajic-Kapetanovic   +14 more
doaj   +1 more source

Dynamin‐Related Protein 1‐Dependent Disruption of Mitochondrial Homeostasis Drives Blue Light‐Induced Epithelial‐Mesenchymal Transition in Retinal Aging

Aging Cell, Volume 25, Issue 2, February 2026.
Blue light causes retinal injury by inducing excessive mitochondrial fission and epithelial‐mesenchymal transition in retinal pigment epithelial cells. Therapeutic targeting of Drp1 rescues this damage, restoring mitochondrial homeostasis and retinal integrity.
Zhi‐Yuan Li, Dashuang Yang, Yongxia Huang, Yintian Li, Tianyun Zhao, Ying Xu   +5 more
wiley   +1 more source

Aptamer Engineering: Strategies for Discovering Functional Nucleic Acids for Next‐Generation Diagnostics and Biosensing

Advanced Science, Volume 13, Issue 2, 9 January 2026.
The advent of aptamers has highlighted their potential as alternatives to antibodies, overcoming limitations of structural instability and production cost. However, conventional approaches such as SELEX remain slow and labor‐intensive. This review examines recent advances in aptamer engineering, emphasizing in vitro and AI‐driven in silico strategies ...
John V. L. Nguyen, Ahlem Meziadi, Cyrill Brunner, Maureen McKeague, Lidija Malic, Maryam Tabrizian   +5 more
wiley   +1 more source

From Supplements to Sight: Quantifying the Impact of Lutein and Carotenoid on Age‐Related Macular Degeneration—A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Journal of Ophthalmology, Volume 2026, Issue 1, 2026.
Purpose To quantify the effects of lutein‐containing supplementation on structural and functional visual outcomes in patients with age‐related macular degeneration (AMD), with particular focus on disease stage and treatment exposure. Methods A meta‐analysis of randomized, placebo‐controlled trials was conducted.
Wei-Xiang Wang, Chen-Chi Wang, Wei-Cherng Hsu, Yi-Jie Peng, Deepali   +4 more
wiley   +1 more source

Time Course of Structural, Functional, Complement Changes and Inflammatory Processes in a Sodium Iodate Rat Model of Geographic Atrophy

The FASEB Journal, Volume 39, Issue 23, 15 December 2025.
A sodium iodate (NaIO3)‐induced geographic atrophy (GA) model in pigmented rats was established using in vivo and histological analyses. Morphological, ultrastructural changes, complement and inflammatory processes were evaluated at pre‐dose and 3, 7, and 14 days post‐NaIO3 injection.
Shiying Zhao, Florian Voegele, Jiaqi Tang, Simon J. Clark, Alexander V. Tschulakow, Sylvie Julien   +5 more
wiley   +1 more source

Geographic Atrophy: Pathophysiology, Diagnosis and Current and Emerging Treatments

TNOA Journal of Ophthalmic Science and Research
Background: Geographic atrophy (GA) is an advanced, irreversible form of age-related macular degeneration (AMD) characterised by progressive loss of photoreceptors, retinal pigment epithelium (RPE) and choriocapillaris.
Alexander G. Maloof, Ava R. James, Nicholas V. Pavic, Shane Zhang, Marcus Pannu, Stephanie Wu, Christohper Go   +6 more
doaj   +1 more source

Design and Evaluation of Sticky End‐Type Bivalent DNA Aptamers Containing M08s‐1 as Anticoagulant Agents

ChemMedChem, Volume 20, Issue 23, November 28, 2025.
Sticky end‐type antithrombin aptamer, composed of two short hybridizable segments, is developed as a potential alternative to conventional anticoagulant drugs. The obtained bivalent aptamer surpasses existing long bivalent aptamers in anticoagulant activity and serum stability, offering advantages in synthesis efficiency and cost‐effectiveness. Aptamer
Maasa Yokomori, Mizuki Murasawa, Muneyuki Matsuo, Masanobu Nagano, Keitaro Yoshimoto   +4 more
wiley   +1 more source

The future of complement therapeutics

Exploration of Immunology
Complement is both evolutionary and scientifically old. It predates the adaptive immunity by some 600 million years and was first described in 1905 by Jules Bordet and Paul Ehrlich. For the most of its, the existence complement system has been ignored by
Martin Kolev, Kollu Nageswara Rao, Michael Yeh, Pascal Deschatelets   +3 more
doaj   +1 more source