Results 41 to 50 of about 33,788 (246)

Investigating the Occurrence of Femoral Head Avascular Necrosis in Patient with Multiple Sclerosis Treated with Interferon-Beta

مجله دانشکده پزشکی اصفهان, 2018
Background: Multiple sclerosis (MS) is a demyelinating inflammatory disease of central nervous system. Avascular necrosis (AVN) of femoral head is reported as an unusual complaint of multiple sclerosis.
Pegah Sadat Fatehi, Masoud Etemadifar
doaj   +1 more source

Freiberg’s Avascular Necrosis: A Case Report

Journal of Orthopedic and Spine Trauma, 2020
Background: Freiberg’s disease is an uncommon condition typified by bony infarction of the second metatarsal head with a vague multifactorial etiology which tends to mostly occur in women. Case Report: A 22-year-old woman presented with second metatarsal
Amir Sabbaghzadeh, Hossein Mohebi, Shiva Momen, Morteza Gholipour, Seyyed-Mohsen Hosseininejad   +4 more
doaj   +1 more source

Drug‐Induced Cuproptosis Defines the Therapeutic Window of Celecoxib in Intervertebral Disc Degeneration via the HSP90‐RBX1 Axis

Advanced Science, EarlyView.
This study reveals the dual role of celecoxib in intervertebral disc degeneration. While low concentrations are protective, high concentrations induce toxicity by upregulating HSP90, which synergizes with USP15 to deubiquitinate and stabilize RBX1. This leads to degradation of COMMD1/ATP7B, copper dyshomeostasis, and ultimately, cuproptosis.
Youfeng Guo, Hongju Xiao, Shenghao Ba, Yu Zhou, Bijun Wang, Bin Yu, Yufeng Huang, Haihong Zhao, Zhefan Stephen Chen, Na Shen, Zhaoyu Ba, Desheng Wu   +11 more
wiley   +1 more source

Predictive value of post-reduction gadolinium-enhanced magnetic resonance imaging in detecting avascular necrosis after closed and open reduction for developmental dysplasia: A minimum 5-year follow-up study

Journal of Children's Orthopaedics
Purpose: We aimed to investigate whether globally decreased enhancement on post-reduction gadolinium-enhanced magnetic resonance imaging can predict avascular necrosis after open or closed reduction for developmental dysplasia of the hip.
Eduardo N Novais, Katharine F Hollnagel, Sarah D Bixby, Mariana G Ferrer, David N Williams, Young-Jo Kim, Florian Schmaranzer   +6 more
doaj   +1 more source

BONE GRAFTING ENHANCED BY PLATELET-RICH PLASMA IN TREATMENT OF AVASCULAR NECROSIS OF FEMORAL HEAD

Travmatologiâ i Ortopediâ Rossii, 2018
Treatment of avascular necrosis of the femoral head is an issue of current interest while it affects young and employable people. So far there is no well-defined strategy of management which would help to postpone hip arthroplasty and further revision ...
A. A. Korytkin, A. A. Zykin, D. V. Zakharova, Ya. S. Novikova   +3 more
doaj   +1 more source

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

Avascular Necrosis of Femoral Head

Geriatric Orthopaedic Surgery & Rehabilitation, 2013
Avascular necrosis (AVN) of the femoral head is a relatively uncommon complication following an extracapsular hip fracture. Although it can occur following fixation of unstable 3-part or 4-part intertrochanteric fractures with significant posteromedial ...
Ravi Mallina MRCS, Feroz Dinah FRCS
doaj   +1 more source

Open Total Talus Dislocation: A Case Report [PDF]

Malaysian Orthopaedic Journal, 2012
Total talus dislocation is a rare injury and is commonly accompanied by associated fractures. Common worrisome sequelae are infection, avascular necrosis and post-traumatic arthritis.
E Tan, HS Chua, CL Ooi, Zulkiflee O
doaj   +1 more source

Cumulative Antigen Suppression Reduces Clonal Plasma Cell Evolution in Gaucher Disease

American Journal of Hematology, EarlyView.
ABSTRACT Chronic antigenic stimulation is implicated in the pathogenesis of monoclonal gammopathy and multiple myeloma, yet longitudinal human evidence linking sustained antigen exposure to modifiable clonal plasma cell evolution remains limited. Gaucher disease (GD), caused by biallelic GBA1 pathogenic variants, is characterized by accumulation of ...
Noor Ul Ain, Noffar Bar, Lilu Guo, Katherine Klinger, Punita Gupta, Atta Ur Rahman, Ruhua Yang, Yanhong Deng, Natalia Neparidze, Shiny Nair, Pramod K. Mistry   +10 more
wiley   +1 more source

Surgical Technique for Treating Focal Osteochondral Knee Lesions Using an Aragonite‐Based Biphasic Scaffold

Arthroscopy Techniques, EarlyView.
Abstract Osteochondral lesions of the knee, particularly in patients with early osteoarthritic changes, remain a clinical challenge. The Agili‐C implant (CartiHeal, Smith & Nephew), an aragonite‐based osteochondral scaffold, offers a single‐stage, off‐the‐shelf solution designed to regenerate both cartilage and subchondral bone.
Eric Wang, Alexandra M. Cancio‐Bello, Katelyn T. Koschmeder, Bryn Berens, Anikar Chhabra   +4 more
wiley   +1 more source