Results 81 to 90 of about 6,160,028 (209)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
The average density of planar Brownian motion [PDF]
, 1997 We show that the occupation measure on the path of a planar Brownian motion run for an arbitrary finite time intervalhas an average density of order three with respect to thegauge function t^2 log(1/t).
Mörters, Peter
core +2 more sources
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Parametric Conditional Monte Carlo Density Estimation [PDF]
In applied density estimation problems, one often has data not only on the target variable, but also on a collection of covariates. In this paper, we study a density estimator that incorporates this additional information by combining parametric ...
John Stachurski, Yin Liao
core
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Pubawidya: Jurnal Penelitian dan Pengembangan Arkeologi, 2017 The science on the existence of maxillary and mandibular cortical bone thickness and density of prehistoric human which had been found from Pawon cave, are still uniden- tified by any research, further more if it is compared with those of modern human ...
Wisam Rizqullah +5 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Spectrum sensing algorithm based on average value of middle part of power spectral density
Dianxin kexue, 2016 The difference between maximum and minimum value of the received signal power spectrum is distinct when the primary user signal is present or absent.Using this characteristic,the spectrum sensing algorithm based on the average of the middle part of power
Zhijin ZHAO, Xi LV, Shilian ZHENG
doaj +2 more sources
Study on voltage characteristics of short air arc with high current density arc root
AIP Advances, 2019 In this paper, the voltage characteristics of short air arc with high average current density arc root were studied at atmospheric pressure. Cu-W electrodes with diameter of 5-14mm and gap length of 0.2-3 mm were used in the experimental study.
Tiansheng Zhu +4 more
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source