Results 131 to 140 of about 4,832,495 (330)
Average sedimentation coefficient from second moment method.
, 2016 Kristian Schilling, Frank Krause
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Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Averaging method in optimal control problems for integro-differential equations
Open MathematicsThe averaging method is applied to the study of optimal control problems for systems of integro-differential equations with rapidly oscillating coefficients and a small parameter.
Lakhva Roksolana +3 more
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Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Periodic oscillations of the relativistic pendulum with friction
Electronic Journal of Differential Equations, 2017 We consider the existence and multiplicity of periodic oscillations for the forced pendulum model with relativistic effects by using the Poincare-Miranda theorem. Some detailed information about the bound for the period of forcing term is obtained. To
Qihuai Liu, Lukai Huang, Guirong Jian
doaj
A Heat Conduction Problem with Sources Depending on the Average of the Heat Flux on the Boundary
, 2019 Mahdi Boukrouche, Domingo A. Tarzia
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Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
On the cohesion and separability of average-link for hierarchical agglomerative clustering [PDF]
Eduardo Sany Laber, Miguel Bastista
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ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source