Results 131 to 140 of about 320,011 (310)
Bayesian Averaging, Prediction and Nonnested Model Selection [PDF]
This paper studies the asymptotic relationship between Bayesian model averaging and post-selection frequentist predictors in both nested and nonnested models.
Han Hong, Bruce Preston
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Perturbed damped pendulum: finding periodic solutions via averaging method
, 2021 Agraïments: The author is supported by a FAPESP-BRAZlL grant 2012/10231-7Using the damped pendulum model we introduce the averaging method to study the periodic solutions of dynamical systems with small non-autonomous perturbation.
Novaes, Douglas D.
core
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
, 2003 The intensity of a laser beam after propagation through turbulent media such as the atmosphere may follow different probability density functions (PDFs) depending on the fluctuation regime. For non-coherent receivers the aperture averaging effect reduces
Perlot, Nicolas +3 more
core
Dual subgradient method with averaging for optimal resource allocation
, 2017 A dual subgradient method is proposed for solving convex optimization problems with linear constraints. As novelty, the recovering of primal solutions can be avoided. Instead, the optimal convergence rate for the whole sequence of primal-dual iterates is
Nesterov, Yurii +3 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Examination of an averaging method for estimating repulsion and attraction interactions in moving groups. [PDF]
PLoS One, 2020 Mudaliar RK, Schaerf TM.
europepmc +1 more source