Results 51 to 60 of about 7,272 (223)

New developments in biotechnology applied to animals: An assessment of the adequacy and sufficiency of current EFSA guidance for animal risk assessment

EFSA Journal, Volume 23, Issue 8, August 2025.
Abstract EFSA was requested by the European Commission to provide a scientific opinion on new developments in biotechnology, including new genomic techniques, as applied to animals for food, feed and other agricultural uses. A horizon‐scanning exercise identified a variety of animals obtained with new genomic techniques, with the potential to reach the
EFSA Panel on Genetically Modified Organisms (GMO), Josep Casacuberta, Francisco Barro, Albert Braeuning, Ruud de Maagd, Michelle M. Epstein, Thomas Frenzel, Jean‐Luc Gallois, Frits Koning, Antoine Messéan, F. Javier Moreno, Fabien Nogué, Alan H. Schulman, Christoph Tebbe, Eve Veromann, Leslie Firbank, Debora Glandorf, Mette S. Herskin, Simon Geoffrey Lillico, Robin Ornsrud, Anna Troedsson‐Wargelius, Michele Ardizzone, Paolo Lenzi, Ana M. Camargo, Nikoletta Papadopoulou, Reinhilde Schoonjans, Marika Vitali, Giovanni Savoini   +27 more
wiley   +1 more source

Intravital Imaging of Immune Responses in the Cancer Microenvironment

Cancer Medicine, Volume 14, Issue 8, April 2025.
ABSTRACT Background To date, many types of immune cells have been identified, but their precise role in cancer immunity remains unclear. Understanding the immune responses involved in cancer and the cancer microenvironment is becoming increasingly important for elucidating disease mechanisms.
Hiroki Hirao, Masaki Honda, Masahiro Tomita, Lianbo Li, Ahmad Adawy, Weijie Xue, Taizo Hibi   +6 more
wiley   +1 more source

The ageing virus hypothesis: Epigenetic ageing beyond the Tree of Life

BioEssays, Volume 47, Issue 1, January 2025.
Viruses would age when the epigenetic signals they need to carry out their life cycle are degraded. Given the abundance and age of viruses, epigenetic aging of viruses would extend theories on the evolution of aging beyond cellular organisms, and encourage new models of viral dynamics and new anti‐viral therapies.
Éric Bapteste
wiley   +1 more source

Prolactin: A Key Immunoregulator in Viral Infections and Autoimmune Diseases

International Journal of Endocrinology, Volume 2025, Issue 1, 2025.
Prolactin (PRL) is secreted by various cells in the anterior pituitary gland, mammary glands, placenta, uterus, ovaries, testes, skin, adipose tissue, endothelial cells, immune system, and central nervous system. The expression and secretion of PRL are influenced by several factors such as suckling, thyrotropin‐releasing hormone (TRH), cytokines ...
Mina Asadikaram, Saeed Bahrampour, Mahdis Rahimi Naiini, Abdollah Jafarzadeh, Clifford Rosen, Gholamreza Asadikaram, Suraiya Saleem   +6 more
wiley   +1 more source

Advances on ALV-J in China over the past two decades

Journal of Integrative Agriculture
Avian leukosis is an important tumorigenic disease caused by the avian leukosis virus (ALV) in poultry. ALVs belong to the retroviral family and are classified into 11 subgroups (ALV-A to ALV-K). Among them, ALV-J was first introduced into China in 1999,
Wenrui Fan, Yuntong Chen, Mengmeng Yu, Yongzhen Liu, Yulong Gao   +4 more
doaj   +1 more source

Enhanced Antiviral Ability by a Combination of Zidovudine and Short Hairpin RNA Targeting Avian Leukosis Virus [PDF]

, 2022
Qun Wang, Qi Su, Bowen Liu, Yan Li, Wanli Sun, Yanxue Liu, Ruyu Xue, Shuang Chang, Yixin Wang, Peng Zhao   +9 more
openalex   +1 more source

Pathology and Molecular Diagnosis of Marek’s Disease Virus in Chickens in Nigeria

Scientifica, Volume 2025, Issue 1, 2025.
Marek’s disease caused by Marek’s disease virus (MDV) serotype 1 is an economically important neoplastic disease of poultry. Diagnosis of this disease is usually based on clinical signs, postmortem lesions, and diagnostic tests like cytology, histopathology, and molecular‐based methods.
Olusegun Adesina Fagbohun, Aiki-Raji Comfort Oluladun, Theophilus Aghogho Jarikre, Olugbenga Olayinka Alaka, Ademola Adetokunbo Oyagbemi, Rofiat Damilola Adesina, Oluwaseun Olanrewaju Esan, Olumide Odunayo Akinniyi, Moses Olusola Adetona, Temidayo Olutayo Omobowale, Ufuoma Joan Mamoh, Ishmael Festus Jaja, Amir Sasan Mozaffari Nejad   +12 more
wiley   +1 more source

MiR-125b Suppression Inhibits Apoptosis and Negatively Regulates Sema4D in Avian Leukosis Virus-Transformed Cells

Viruses, 2019
Subgroup J avian leukosis virus (ALV-J), an oncogenic retrovirus, causes hemangiomas and myeloid tumors in chickens. We previously showed that miR-125b is down-regulated in ALV-J-induced tumors.
Chaoqi Ren, Ruyu Xie, Yongxiu Yao, Mengmeng Yu, Fangfang Chang, Lixiao Xing, Yao Zhang, Yongzhen Liu, Suyan Wang, Muhammad Farooque, Yongqiang Wang, Xiaole Qi, Changjun Liu, Yanping Zhang, Hongyu Cui, Kai Li, Li Gao, Qing Pan, Venugopal Nair, Xiaomei Wang, Yulong Gao   +20 more
doaj   +1 more source

Rodent models of tumours of the central nervous system

Molecular Oncology, Volume 18, Issue 12, Page 2842-2870, December 2024.
We describe the evolution of experimental systems, illustrated here in a timeline to show changing popularity over time. Starting with chemical and viral carcinogenesis, systems then developed into increasingly sophisticated genetically modified animal models.
Sebastian Brandner
wiley   +1 more source

Posterior Basolateral Amygdala is a Critical Amygdaloid Area for Temporal Lobe Epilepsy

Advanced Science, Volume 11, Issue 48, December 26, 2024.
This study identifies the posterior basolateral amygdala (pBLA) as a critical nucleus in the regulation of temporal lobe epilepsy (TLE) within the amygdaloid complex. It highlights the distinct roles of both upstream and downstream neural circuits of the pBLA in modulating epileptic seizures.
Yan‐Hui Sun, Bo‐Wu Hu, Li‐Heng Tan, Lin Lin, Shu‐Xia Cao, Tan‐Xia Wu, Hao Wang, Bin Yu, Qin Wang, Hong Lian, Jiadong Chen, Xiao‐Ming Li   +11 more
wiley   +1 more source