Results 151 to 160 of about 70,006 (293)
Advanced Science, EarlyView.CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu +13 more
wiley +1 more source
Obesity and the Incidence of Chronic Diseases: a Seemingly Unrelated Probit Approach [PDF]
Western societies can reduce avoidable mortality and morbidity by better understanding the relationship between obesity and chronic disease. This paper examines the joint determinants of obesity and of heart disease, diabetes, hypertension, and elevated ...
Joan Costa Font, Joan Gil Trasfi
core +1 more source
G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis
Advanced Science, EarlyView.Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang +9 more
wiley +1 more source
A Metal‐Free Carbon Monoxide Prodrug Suppresses Metastasis of Pancreatic and Breast Cancer
Advanced Science, EarlyView.A metal‐free carbon monoxide (CO) prodrug, CO‐116, delivers controlled systemic CO without inhalation. CO suppresses the HRG1–heme axis, reducing intracellular heme availability. Attenuation of this pathway inhibits metastatic progression in pancreatic and triple‐negative breast cancer models.
Tiantian Zhang +15 more
wiley +1 more source
Gaceta Sanitaria, 2005 Objetivos: Analizar la evolución temporal y la distribución geográfica por sectores sanitarios de la mortalidad evitable en Cataluña. Material y métodos: Se analizó la mortalidad evitable según la clasificación utilizada en el Departamento de Salud de ...
M. Arán Barés +4 more
doaj
Mortality in Catalonia in the context of the third, fourth and future phases of the epidemiological transition theory [PDF]
In the period 1960-2000, male and female life expectancy increased by 8,2 and 10,5 years, respectively, in Catalonia, one of Spain’s Autonomous Regions, to one of the highest in the world.
Amand Blanes Llorens, Jeroen Spijker
core
Macrophage Extracellular Traps in Immunity and Cancer
Advanced Science, EarlyView.As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li +5 more
wiley +1 more source
Advanced Science, EarlyView.We developed an implantable dual‐drug depot using GelMA for bone metastasis treatment, co‐delivering MSA‐2 and αB7‐H3‐loaded CaCO3 microparticles. Sustained release from GelMA scaffold enables MSA‐2 to activate STING signaling and enhance T‐cell infiltration and activation, while sequentially released αB7‐H3 blocks MSA‐2‐induced B7‐H3 upregulation ...
Qijun Lin +10 more
wiley +1 more source
Mortalidad evitable, Medellín 2004 a 2009/ Avoidable mortality, Medellín 2004 to 2009
Revista Facultad Nacional de Salud Pública, 2013 Objetivo: determinar la estructura de la mortalidad evitable en Medellín entre 2004 y 2009 y de los Años Potenciales de Vida Perdidos (apvp). Metodología: en un estudio descriptivo con información del dane, se utilizó el Inventario de Causas de ...
Ana M. Pérez +2 more
doaj
Avoidable Mortality between Metropolitan and Non-Metropolitan Areas in Korea from 1995 to 2019: A Descriptive Study of Implications for the National Healthcare Policy. [PDF]
Int J Environ Res Public Health, 2022 Choi MH, Moon MH, Yoon TH.
europepmc +1 more source