Results 171 to 180 of about 70,006 (293)

Generation of CCR4/CD7 Bispecific CAR‐T Cells Resistant to Fratricide and Exhaustion

Advanced Science, EarlyView.
The applications of CAR T‐cell therapy in T‐cell malignancies face limitations such as fratricide, effector‐cell exhaustion, and antigen‐escape. Herein, we developed fratricide‐ and exhaustion‐resistant CAR‐T cells that targeted CCR4 and CD7 simultaneously, with optional EGFRt safety switch. Additionally, scRNA‐seq unveiled new molecular targets, which
Sile Li, Yuanxin Li, Asif Rashid, Hong Kee Tan, Shing Chan, Man Yan Hui, Wilson Yau Ki Chan, Kee See Lam, Yinping Liu, Wenwei Tu, Wing Leung   +10 more
wiley   +1 more source

Avoidable Mortality Burden Attributable to PM2.5 in Madrid (Spain). [PDF]

Open Respir Arch
López-Encuentra Á, Gil Cid E, Abraira V, Pozo Coronado LM, Coordinadora Vecinal Distrito Latina (COVELA), the Asociación Madres por el Clima Lourdes.   +5 more
europepmc   +1 more source

Trends in socioeconomic inequalities in premature and avoidable mortality in Canada, 1991-2016. [PDF]

CMAJ, 2020
Shahidi FV, Parnia A, Siddiqi A.
europepmc   +1 more source

Child social exclusion and health outcomes: a study of small areas across Australia [PDF]

Australian children living in areas with a relatively high risk of social exclusion also experience relatively poor health outcomes, argues this bulletin.

core  

Bacterial Outer Membrane Vesicles in Potentiating Cancer Vaccines: Progress and Prospects

Advanced Science, EarlyView.
Bacterial outer membrane vesicles (OMVs) have emerged as versatile platforms for cancer vaccine development owing to their intrinsic immunostimulatory properties and high engineering flexibility. This review summarizes OMV biology, immune mechanisms, and engineering strategies that enhance vaccine efficacy, discusses key translational challenges, and ...
Jiabeini Zhang, Tianyu Shao, Fengjiang Qu, Caiyun Bai, Sijie Li, Pin Gao, Wenna Li, Keman Cheng, Xiao Zhao, Zhimin Fan   +9 more
wiley   +1 more source

The Association between Material Deprivation and Avoidable Mortality in Lisbon, Portugal. [PDF]

Int J Environ Res Public Health, 2020
Costa C, Freitas A, Almendra R, Santana P.   +3 more
europepmc   +1 more source

Bench‐to‐Bedside Translation of Self‐Healing Colloidal Hydrogels as Next Generation Design of Flowable Hemostatic Matrix: From Preclinical Evaluation to Human Clinical Trials

Advanced Science, EarlyView.
ABSTRACT Self‐healing materials represent a paradigm shift in designing functional biomedical devices for drug delivery, tissue regeneration, and 3D bioprinting. However, their clinical translation remains limited by challenges such as insufficient mechanical strength, potential cytotoxicity from chemical modifications, and complex activation ...
Ganjun Feng, Kaiwen Chen, Qiwei Ying, Shuya Wang, Xin Li, Guanlin Li, Yantao Zhao, Binghua Ma, Huanan Wang, Dawei Li, Lijun Zhang, Jian Zhang, Yu Zhao, Changle Ren, Baodong Chen, Yueming Song   +15 more
wiley   +1 more source

Selective Inhibition of Integrin β3 Topology Provides a Safer Antithrombotic Strategy

Advanced Science, EarlyView.
Current integrin αIIbβ3 inhibitors effectively reduce thrombosis but also increase bleeding risk. During thrombosis, high shear blood flow can directly activate the integrin αIIbβ3 via a distinct topological change in the β3 transmembrane domain, independent of hemostatic platelet signaling.
Joonha Lee, Chul‐Gyun Lim, Pothiappan Vairaprakash, Jong‐Min Kim, Jiyoon Kim, Ji‐Young Park, Klaus M. Hahn, Hyunbo Shim, Hae Woong Choi, Tobias S. Ulmer, Soon Jun Hong, Chungho Kim   +11 more
wiley   +1 more source

Different health systems - Different mortality outcomes? Regional disparities in avoidable mortality across German-speaking Europe, 1992-2019.

Soc Sci Med, 2023
Mühlichen M, Lerch M, Sauerberg M, Grigoriev P.   +3 more
europepmc   +1 more source

Avoidable Mortality Attributable to Anthropogenic Fine Particulate Matter (PM_2.5) in Australia. [PDF]

Int J Environ Res Public Health, 2020
Hanigan IC, Broome RA, Chaston TB, Cope M, Dennekamp M, Heyworth JS, Heathcote K, Horsley JA, Jalaludin B, Jegasothy E, Johnston FH, Knibbs LD, Pereira G, Vardoulakis S, Vander Hoorn S, Morgan GG.   +15 more
europepmc   +1 more source