Results 101 to 110 of about 1,393,402 (283)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
FATHOMING TAX HAVENS CLIMATE THROUGH A CONSEQUENTIALIST VERSUS A DEONTOLOGICAL MORAL LENS [PDF]
Analele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie, 2014 By means of an extensive methodological apparatus including analysis of chain base indexes, comparisons, syntheses and case studies, literature review of scientific articles, books or official documents released by international organizations and ...
LARISSA BǍTRÂNCEA +2 more
doaj
Risk management methods of factoring business and its accounting support
Vìsnik Žitomirsʹkogo Deržavnogo Tehnologìčnogo Unìversitetu: Ekonomìčnì Nauki, 2018 Factoring business is constantly under the conditions of business risk. The management system of factoring company requires a new qualitative level of accounting information in order to minimize the negative effects of the risks as well as efficiency of ...
I.M. Vygivska, V.K. Makarovych
doaj +1 more source
Pathogen avoidance by insect predators [PDF]
, 2008 Insects can detect cues related to the risk of attack by their natural enemies. Pathogens are among the natural enemies of insects and entomopathogenic fungi attack a wide array of host species.
Meyling, Nicolai V. +3 more
core
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Evaluation of Behaviour to Pain Measures in Athletes - A Correlative Analysis
Montenegrin Journal of Sports Science and Medicine, 2013 Research suggests that pain affects behaviour of the athletes, assessment of behaviour when in pain reveals that pain has influenced athletes’ measurable response when they get injured in their course of play. The objectives of the study were to find and
Praveen Kumar +2 more
doaj
Frontiers in Behavioral Neuroscience, 2016 The avoidance response is present in pathological anxiety and interferes with normal daily functions. The aim of this article is to shed light on performance markers of active avoidance (AA) using two different rat strains, Sprague-Dawley (SD) and Wistar.
Caroline Cruz Oliveira +8 more
doaj +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Brain Sciences, 2019 Fragile X syndrome (FXS) is a genetic condition known to increase the risk of cognitive impairment and socio-emotional challenges in affected males and females.
Kristi L. Bartholomay +4 more
doaj +1 more source