Results 81 to 90 of about 556,178 (316)
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
UAV collision avoidance: a specific acceleration matching approach
, 2011 Includes abstract.Includes bibliographical references.An increased level of autonomy is required for future Unmanned Aerial Vehicle (UAV) missions. One of the technologies required for this to occur is an adequate sense and avoid system to enable the UAV
Patel, Amir
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Voting over tax schedules in the presence of tax avoidance [PDF]
This paper reconsiders the classical problem of majority voting over tax schedules, adding the possibility to avoid taxes. In this setting preferences over tax schedules are not determined by earned income, but rather by taxable income, which depends on ...
Roine, Jesper
core
Visual cueing for collision avoidance system [PDF]
, 2012 The modern Traffic Alert and Collision Avoidance System (TCAS) used in airlines today is the TCAS II. It provides pilots with both Traffic Advisory (TA) and Resolution Advisory (RA) which in turn reduces the incidence of mid-air collisions.
Li, Huiying
core
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Perfectionism and achievement goals in athletes: Relations with approach and avoidance orientations in mastery and performance goals [PDF]
, 2008 Objectives: Challenging views that perfectionism is a maladaptive factor in sport and that it is related to a preoccupation with performance goals and a neglect of mastery goals, the present article argues that perfectionism in athletes is not generally ...
Stoeber, Joachim +7 more
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Perceived control and avoidance in posttraumatic stress
European Journal of Psychotraumatology, 2018 Despite much evidence concerning the importance of control over stressors in animal models of adaptation to stress, there is a dearth of experimental evidence for the role of controllability in posttraumatic stress disorder (PTSD).
Lisa Hancock, Richard A. Bryant
doaj +1 more source