Results 171 to 180 of about 1,002,275 (287)

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

A conceptual framework for the diagnostic pathology of anxiety disorders: Clinical and pathological tetrads for identifying pathological anxiety. [PDF]

Indian J Psychiatry
Manjunatha N.
europepmc   +1 more source

Determinants of undergraduate bioscience engagement: Validating attendance barriers and classroom spatial behaviour across institutions

FEBS Open Bio, EarlyView.
Student engagement extends beyond simple attendance. Across 891 bioscience students from three universities, attendance behaviour was associated mainly with structural influences, whereas classroom spatial behaviour reflected affective and sensory factors.
Nigel Page, Rachel J. Hunt, Lauren J. Albee, Daniel Berwick, Alison Snape   +4 more
wiley   +1 more source

Professional death avoidance and associated factors among intensive care unit nurses in China: a multicenter cross-sectional study. [PDF]

Front Med (Lausanne)
Luo T, Hu C, Tang L, Zhong Y, Zhao Y, Wang H, Feng Y, Yang Q.   +7 more
europepmc   +1 more source

The Fear-Avoidance Model of Musculoskeletal Pain: Current State of Scientific Evidence

Journal of behavioral medicine, 2006
M. Leeuw, M. Goossens, S. Linton, G. Crombez, K. Boersma, J. Vlaeyen   +5 more
semanticscholar   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

What patients do when they feel dizzy: behavioural signatures reveal diagnostic clues in common vestibular disorders. [PDF]

J Neurol
Ozdemir HN, Klopotovska I, Kaski D.
europepmc   +1 more source

Understanding Further the Phenotypic Spectrum of Central Nervous System Inflammatory Demyelinating Disorders Using Unsupervised Clustering

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Central nervous system (CNS) inflammatory demyelinating syndromes, including multiple sclerosis (MS), aquaporin‐4 antibody–positive neuromyelitis optica spectrum disorder (AQP4 + NMOSD), and myelin oligodendrocyte glycoprotein (MOG) antibody–associated disease (MOGAD), occasionally overlap.
Bade Gulec, Elif Everest, Melih Tutuncu, Ugur Bilge, Sabahattin Saip, Ugur Uygunoglu, Aksel Siva   +6 more
wiley   +1 more source

Pain Sensitivity, Pain Catastrophizing and Fear-Avoidance in Adult Runners: Injured vs. Uninjured Comparisons and Multivariable Associations. [PDF]

Eur J Pain
Pallante P, Hooyman A, Sanchez N, Sigward S, Beisheim-Ryan E, Smith JA, Farrokhi S.   +6 more
europepmc   +1 more source

Experiential Avoidance and Behavioral Disorders: A Functional Dimensional Approach to Diagnosis and Treatment

, 2003
Steven C. Hayes, K. Wilson, E. Gifford, V. Follette, K. Strosahl   +4 more
semanticscholar   +1 more source