NIDDK at 75 Years of Age: Great Triumphs but Concerns for Its Longevity. [PDF]
DiabetesKahn SE +4 more
europepmc +2 more sources
Proceedings of the 92nd Annual Business Meeting of the American Association of Biological Anthropologists. [PDF]
Am J Biol AnthropolRector AL.
europepmc +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Rolf and Gertrud Dahlgren Prize for 2023 Awarded to Louis Ronse De Craene [PDF]
Ib Friis, Natasha de Vere
openalex +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
The Lasker~Koshland Special Achievement Award in Medical Science awarded to Lucy Shapiro. [PDF]
Proc Natl Acad Sci U S AVosshall LB.
europepmc +1 more source
2014 Nobel Prize for Physiology/Medicine awarded to the discovery of 'place cells' in brain
, 2019 Sneha Kulkarni
openalex +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Science and prizes : A case for rethinking the criteria for prizes in science (and for rewarding important discoveries in bacterial physiology). [PDF]
EMBO RepNorris V.
europepmc +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source