Results 71 to 80 of about 585,086 (318)

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Climate Change Awareness and Vulnerability among Farming Communities of Konkan Region, Maharashtra, India

, 2023
This research paper presents an analysis of awareness and vulnerability to climate change among farming communities in a specific study area. The study focuses on understanding the level of awareness among respondents regarding climate change and its ...
Shelar , Rohit, Singh , Arun Kumar, Yarazari , Shivananda P., Maji , Saikat   +3 more
core   +1 more source

Dealing with Changes of Time-Aware Processes [PDF]

, 2014
The proper handling of temporal process constraints is crucial in many application domains. Contemporary process-aware information systems (PAIS), however, lack a sophisticated support of time-aware processes. As a particular challenge, the execution of time-aware processes needs to be flexible as time can neither be slowed down nor stopped.
Andreas Lanz, Manfred Reichert
openaire   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Awareness of everyday effects of climate change: The climate change perceptual awareness scale (CCPAS)

Heliyon
Climate change is intrinsically complex and demands a certain degree of abstraction. However, different individuals report a wide range and degree of tangible and sensory experiences of climate change. As perceptual and sensory awareness of climate change has important consequences for the promotion of sustainable behaviors, pro-climate policies, and ...
Cipriani E., Gemignani A., Menicucci D.
openaire   +2 more sources

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Cancer symptom awareness and barriers to symptomatic presentation in England – Are we clear on cancer? [PDF]

, 2015
Background: Low cancer awareness may contribute to delayed diagnosis and poor cancer survival. We aimed to quantify socio-demographic differences in cancer symptom awareness and barriers to symptomatic presentation in the English population.
Niksic, Maja, Rachet, B., A J Ramirez, L J L Forbes, Forbes, L. J L, M Niksic, Warburton, F.G., Warburton, FG, Ramirez, AJ, B Rachet, Ramirez, A.J., Rachet, B, Forbes, LJL, Forbes, L.J.L., Wardle, J., J Wardle, F G Warburton, Warburton, Fiona, Ramirez, A. J., Niksic, M, Wardle, J   +20 more
core   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Enhancing climate change communication: Strategies for profiling and targeting Australian interpretive communities

, 2013
This research aimed to provide practical information about how to design communications on climate change adaptation and target these to the Australian population.
Reser, Joseph, Hine, Donald, Hine, Donald W, Phillips, Wendy J, Ellul, Michelle, Reser, Joseph P, Watt, Susan, Cooksey, Ray W, Marks, Anthony, Nunn, Patrick, Watt, Susan E, Phillips, Wendy, Cooksey, Ray   +12 more
core