Results 171 to 180 of about 934,167 (187)

Multi‐Tissue Crosstalk Regulating Meniscus Healing Under Inflammation and Physiological Loading

Advanced Science, EarlyView.
Using a novel Meniscus‐on‐a‐chip (MoC) model integrated with a meniscus‐specific bioreactor, this study investigated the roles of multi‐tissue crosstalk that regulates injury, healing, and degeneration of the meniscus injury under inflammation and pathophysiological loading.
Hun Jin Jeong, Elen Zhu, Min Seo Kang, Ming Wang, Sam Comito, Chang H. Lee   +5 more
wiley   +1 more source

Smart Bioinks for 4D Bioprinting: Requirements, Design, and Applications

Advanced Science, EarlyView.
Smart bioinks empower 4D‐bioprinted constructs to dynamically adapt and remodel in response to stimuli, effectively biomimicking native tissues. Artificial Intelligence (AI) and Machine Learning (ML) play a guiding role in their rational design by optimizing relevant properties.
Shangsi Chen, Jiahui Lai, Qiongjiao Zeng, Liangbin Zhou, Boguang Yang, Bin Zhang, Min Wang, Jiajing Zhou, Kieran Lau, Khoon S. Lim, Zhong Alan Li, Rocky S. Tuan   +11 more
wiley   +1 more source

Adaptive Network Stabilization Despite Profound Structural Reorganization in Human Organotypic Cultures

Advanced Science, EarlyView.
Adult human organotypic cortical slices undergo marked neuronal loss, laminar disruption, and glial activation, yet their network activity progressively stabilizes after a variable period. Electrophysiology, longitudinal calcium imaging, and quantitative histology show that structurally remodeled human circuits show adaptive capacity resulting in ...
Estilla Zsófia Tóth, Rebeka Stelcz, Réka Bod, Ábel Petik, Eszter Juhász, Kinga Tóth, Liza Szalai, Nour Essam, Fanni Somogyi, Beatrix Kovács, Amirmahdi Mojtahedzadeh, Attila György Bagó, Loránd Erőss, Péter Orbay, Johanna Petra Szabó, Dániel Fabó, Boglárka Hajnal, Bence Rácz, Daniel Hillier, István Ulbert, Lucia Wittner   +20 more
wiley   +1 more source

Lactylation‐Driven PROS1‐TYRO3‐CARF Signaling Promotes Therapy‐Induced Senescence Escape and Radioresistance in Meningioma

Advanced Science, EarlyView.
A glycolysis‐driven epigenetic switch promotes therapy resistance in meningioma. Increased lactate production enhances histone H3K27 lactylation, which activates PROS1 secretion. Secreted PROS1 engages TYRO3 signaling to degrade the senescence regulator CARF, allowing cancer cells to escape growth arrest.
Zhuohang Wang, Qixiang Zhang, Keman Liao, Xiaoyu Liu, Hongchi Zhang, Yunsheng Chen, Yuxiao Ma, Yikui Liu, Aoqian Xu, Yuhao Sun, Jiayi Chen, Liuguan Bian, Baofeng Wang   +12 more
wiley   +1 more source

Method for Design of Integral Shaped Milling Cutter Profile

Advanced Materials Research, 2011
Nowadays the profile of integral shaped milling cutter is designed by diagram method. This method is low efficiency and bad precision. This paper deals with the application of conjugate surface theory to the profile design of integral shaped milling ...
Qing Yun Sun, Yu Xia Shan, Zhao Wu Wang, Yan Feng Bai   +3 more
exaly   +2 more sources

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Analysis of Rock-Breaking Mechanism and Drillstring Dynamics of an Innovative Multi-Ridge-Curve-Shaped PDC Cutter

Arabian Journal for Science and Engineering, 2023
Weiji Liu, Xiaohua Zhu
exaly  

Cutting mechanism of a special 3D concave-shaped PDC cutter applicable to the Weiyuan shale

Journal of Petroleum Exploration and Production, 2023
Jinsheng Sun, Xiaohua Ke
exaly  

Preliminary investigation on flexible cutting technology for rotating shaped cutter

Geoenergy Science and Engineering, 2023
Deng Zhang
exaly  

Rock cutting mechanism of special-shaped PDC cutter in heterogeneous granite formation

Journal of Petroleum Science and Engineering, 2022
Weiji Liu, Xiaohua Zhu, Yunxu Luo
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The optimal cutter orientation in ball end milling of cantilever-shaped thin plate

Journal of Materials Processing Technology, 2004
D W Lee, C M Lee
exaly