Results 91 to 100 of about 2,349,133 (334)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Nanometric axial localization of single fluorescent molecules with modulated excitation

open access: yesNature Photonics, 2019
Distance measurements are commonly performed by phase detection based on a lock-in strategy. Super-resolution fluorescence microscopy is still striving to perform axial localization but through entirely different strategies.
P. Jouchet   +6 more
semanticscholar   +1 more source

Bubble-Driven Inertial Micropump

open access: yes, 2012
The fundamental action of the bubble-driven inertial micropump is investigated. The pump has no moving parts and consists of a thermal resistor placed asymmetrically within a straight channel connecting two reservoirs.
Alexander N. Govyadinov   +7 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Vegetable oil characteristics enhance the phytotoxicity of pinoxaden and haloxyfop-R-methyl on littleseed canarygrass Phalaris minor Retz.

open access: yesJournal of Crop Protection, 2020
It is possible to increase the efficacy of herbicides by adding vegetable oils to the spray tank. In order to evaluate and study this fact a greenhouse study was conducted.
Mehdi Rastgoo   +2 more
doaj  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Methods of analysis of a reinforced concrete section under bending with axial force in the post-yield range

open access: yesBudownictwo i Architektura, 2014
Predicting the behaviour of plastic hinges subjected to large inelastic deformations caused by extreme loads such as earthquakes plays an important role in assessing maximum stable deformation capacities of framed concrete structures. This paper presents
Jacek Korentz
doaj   +1 more source

Chiral Corrections to Hyperon Axial Form Factors

open access: yes, 2008
We study the complete set of flavor changing hyperon axial current matrix elements at small momentum transfer. Using partially quenched heavy baryon chiral perturbation theory, we derive the chiral and momentum behavior of the axial and induced ...
B. Borasoy   +3 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

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