Results 191 to 200 of about 2,349,133 (334)

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Differences in Ocular Biometry Between Short-Axial and Normal-Axial Eyes in the Elderly Japanese

Clinical Ophthalmology
Takahiro Tanaka,* Koichi Nishitsuka,* Hiroto Obata* Department of Ophthalmology, Saitama Medical Center, Saitama Medical University, Kawagoe-shi, Saitama, Japan*These authors contributed equally to this workCorrespondence: Koichi ...
Tanaka T, Nishitsuka K, Obata H
doaj  

Biomechanical Fracture Thresholds of the Tibia and Fibula Under Axial and Multi-axial Loading: A Systematic Review. [PDF]

Cureus
Zain Ul Abidin M, Mumtaz M, Shetty S, Shehata Abdelmesih SR, Suliman MGH, Abdullah S.   +5 more
europepmc   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

The feasibility and accuracy of real-time intra-operative confocal tissue diagnosis in brain and spine cancer surgery. [PDF]

Neurosurg Rev
Bolton WS, Adebola O, Ramakrishnan PK, Reveendran D, Crispi V, Digby R, Sinha R, Chakrabarty A, Mathew RK.   +8 more
europepmc   +1 more source

Increased Extra-axial Cerebrospinal Fluid in High-Risk Infants Who Later Develop Autism.

Biological Psychiatry, 2017
M. Shen, S. H. Kim, R. McKinstry, H. Gu, H. Hazlett, C. Nordahl, R. W. Emerson, D. Shaw, J. Elison, M. Swanson, Vladimir S Fonov, G. Gerig, Stephen R Dager, K. Botteron, S. Paterson, R. Schultz, A. Evans, A. Estes, L. Zwaigenbaum, M. Styner, David G. Amaral, J. Piven, J. Piven, H. Hazlett, C. Chappell, Stephen R Dager, A. Estes, D. Shaw, K. Botteron, R. McKinstry, J. Constantino, J. Pruett, R. Schultz, L. Zwaigenbaum, J. Elison, A. Evans, D. L. Collins, G. Pike, Vladimir S Fonov, P. Kostopoulos, S. Das, G. Gerig, M. Styner, H. Gu   +43 more
semanticscholar   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Acute deep neck infection MRI: deep learning segmentation and clinical relevance of retropharyngeal edema volume. [PDF]

Eur Radiol Exp
Viertonen VS, Sirén A, Nyman M, Huhtanen H, Klén R, Hirvonen J, Rainio O.   +6 more
europepmc   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Optimizing Drilling Orientation for the ALL Femoral Tunnel During Anterolateral Augmentation Procedures For Minimizing Collision With the ACL Tunnel Created Using Modified Transtibial Technique. [PDF]

Orthop J Sports Med
Choi CH, Kim SH, Seo YJ, Jung M, Chung K, Jung SH, Lee J, Choi SS, Moon HS.   +8 more
europepmc   +1 more source