Results 171 to 180 of about 5,747,014 (299)

In Vivo Human Cone Photoreceptor Inner Segment Diameter Database Using Adaptive Optics Retinal Imaging. [PDF]

Invest Ophthalmol Vis Sci
Aguilera N, Iyer S, Cruz MJ, Li J, Wall M, Kallem M, Volkov A, Brooks BP, Zein WM, Huryn LA, Liu T, Tam J.   +11 more
europepmc   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Spectacle Lenses With Highly Aspherical Lenslets for Myopia Control: A Randomized Clinical Trial.

JAMA Ophthalmol
Shen J, Hunt C, Young G, Drobe B.
europepmc   +1 more source

Optic Nerve Head Parameters and Their Associations With Axial Length and Refractive Status in Cynomolgus Macaques. [PDF]

Invest Ophthalmol Vis Sci
Luo R, Li Y, Xie R, Wang Z, Zhang Y, Zhan J, Chen K, Ye G, Yu J, Leng Y, Zhu Y, Zhuo Y.   +11 more
europepmc   +1 more source

Arterial Spin‐Labeling MRI at the Cortical‐CSF Interface: A Novel Biomarker in Alzheimer Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background/Objective Arterial spin‐labeling (ASL) MRI can measure perfusion signal adjacent to CSF spaces and may provide information regarding CSF‐adjacent water transport physiology. We developed an automated pipeline to extract cortical‐CSF interface (IF) perfusion for comparison between Alzheimer disease (AD) and cognitively normal ...
Mona Asghariahmadabad, Pouya Metanat, Michael Thomas, Luke W. Bonham, Tyson Lam, Mehmet Kurt, Hong Nguyen, Tara Ellingson, Mauro Zucchelli, Stefano Casagranda, Quin Lu, Andreas M. Rauschecker, Leo Sugrue, Luis E. Savastano, Christopher P. Hess, Kamalini Ranasinghe, S. Andrew Josephson, Bruce L. Miller, Jennifer S. Yokoyama, Gil D. Rabinovici, Peter A. Ljubenkov, Lawren VandeVrede, Kambiz Nael   +22 more
wiley   +1 more source

Global Axial Length Centile Charts.

JAMA Ophthalmol
Kneepkens SCM, Lingham G, van Hemert DJ, Loughman J, Strang NC, Tham YC, Harrington SC, Guisasola L, French A, He X, Mackey DA, Hagen LA, Baraas RC, Pärssinen O, Yam JC, Saunders KJ, Guggenheim JA, Saw SM, Lan WZ, Klaver CCW, Flitcroft DI, CREAM-Kids Consortium.   +21 more
europepmc   +1 more source

CSF Cytokine Network Organization Predicts Progression Independent of Relapse and MRI Activity in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Progression independent of relapse activity is a major determinant of long‐term disability in multiple sclerosis, but its immunopathologic basis remains incompletely understood. We investigated whether relapse‐independent progression in radiologically stable relapsing–remitting multiple sclerosis is associated with distinct ...
Antonio Bruno, Matteo Conti, Ettore Dolcetti, Federica Azzolini, Angela Borrelli, Roberta Fantozzi, Mario Stampanoni Bassi, Giovanni Galifi, Giuseppe Maccarrone, Luca Montaguti, Marco Cervigni, Maddalena Dal Pozzo, Roberto Furlan, Annamaria Finardi, Girolama Alessandra Marfia, Marco Salvetti, Antonella Conte, Fabio Buttari, Diego Centonze, Luana Gilio   +19 more
wiley   +1 more source

Photopic pupil size, foveal anatomy and emmetropisation: a cross-sectional study in adult eyes. [PDF]

BMJ Open Ophthalmol
Domdei N, Vohnsen B, Wahl S, Harmening W.   +3 more
europepmc   +1 more source

White Matter and Perivascular Imaging Changes in Alzheimer's Disease and Cerebral Amyloid Angiopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Peak‐width of skeletonized mean diffusivity (PSMD) and diffusion tensor imaging–analysis along the perivascular space (DTI‐ALPS), reflecting white matter integrity and glymphatic function, are altered in Alzheimer's disease (AD).
Debina Laishram, Guangwei Du, Sangam Kanekar, Nandakumar Nagaraja   +3 more
wiley   +1 more source

Morphometric Analysis of Retinal Vessels Using High-Resolution OCT Technology in Healthy Subjects. [PDF]

Invest Ophthalmol Vis Sci
Cozzi M, Motta V, Longoni A, Trinco A, Staurenghi G, Invernizzi A.   +5 more
europepmc   +1 more source