Genome-wide analysis points to roles for extracellular matrix remodeling, the visual cycle, and neuronal development in myopia [PDF]
, 2012 Myopia, or nearsightedness, is the most common eye disorder, resulting primarily from excess elongation of the eye. The etiology of myopia, although known to be complex, is poorly understood. Here we report the largest ever genome-wide association study (
Do, Chuong B. +6 more
core +5 more sources
Ocular Refraction at Birth and Its Development During the First Year of Life in a Large Cohort of Babies in a Single Center in Northern Italy [PDF]
, 2020 The purpose of this study was to investigate refraction at birth and during the first year of life in a large cohort of babies born in a single center in Northern Italy.
Bartollino S. +7 more
core +1 more source
Current trends among pediatric ophthalmologists to decrease myopia progression—an international perspective [PDF]
, 2018 Purpose To explore what the current worldwide preferred practice patterns of pediatric ophthalmologists are to decrease myopia progression among their patients.
Farzavandi, Sonal K. +5 more
core +1 more source
Time outdoors and the prevention of myopia [PDF]
, 2015 Recent epidemiological evidence suggests that children who spend more time outdoors are less likely to be, or to become myopic, irrespective of how much near work they do, or whether their parents are myopic.
Ashby, Regan S. +3 more
core +1 more source
Myopia and defocus: the current understanding [PDF]
, 2011 The current theories relating to the development and progression of myopia are related to exposure of the eye to hyperopic defocus. This paper discusses these theories and the large body of recent research investigating the evidence behind them.
Day, Mhairi, Duffy, Lorraine
core +2 more sources
Changes in forward light scatter parameters as a function of refractive error in young adults [PDF]
, 2020 Background/aims Some aspects of visual performance worsen with increasing myopia. Whilst the underlying causes are not always clear, reduction in retinal image quality is often attributed to structural changes in the posterior myopic eye.
Barbur, J., Nagra, M., Patel, M.
core +2 more sources
Myopes have significantly higher serum melatonin concentrations than non-myopes [PDF]
, 2017 Purpose Experimental animal models of myopia demonstrate that higher melatonin (Mel) and lower dopamine (DA) concentrations actively promote axial elongation.
Ackermann +70 more
core +2 more sources
Human PrimPol mutation associated with high myopia has a DNA replication defect [PDF]
, 2014 PrimPol is a primase-polymerase found in humans, and other eukaryotes, involved in bypassing lesions encountered during DNA replication. PrimPol employs both translesion synthesis and repriming mechanisms to facilitate lesion bypass by the replisome ...
Aguilera +27 more
core +1 more source
Ocular hypertension in myopia: analysis of contrast sensitivity [PDF]
, 2018 Purpose: we evaluated the evolution of contrast sensitivity reduction in patients affected by ocular hypertension and glaucoma, with low to moderate myopia.
Arrico, L +4 more
core +1 more source
Conjunctival ultraviolet autofluorescence area, but not intensity, is associated with myopia [PDF]
, 2019 Background:Conjunctival ultraviolet autofluorescence (CUVAF) has been used as a biomarker of time spent outdoors and smaller CUVAF area is associated with myopia in Southern Hemisphere cohorts.
Healy, Martin +6 more
core +2 more sources