Results 41 to 50 of about 134,424 (302)

Omics in Myopia [PDF]

Journal of Clinical Medicine, 2020
Myopia is a globally emerging issue, with multiple medical and socio-economic burdens and no well-established causal treatment thus far. A better insight into altered biochemical pathways and underlying pathogenesis might facilitate early diagnosis and treatment of myopia, ultimately leading to the development of more effective preventive and ...
Emil Tomasz Grochowski, Karolina Pietrowska, Tomasz Kowalczyk, Zofia Mariak, Adam Kretowski, Michal Ciborowski, Diana Anna Dmuchowska   +6 more
openaire   +3 more sources

Advanced Experiment Design Strategies for Drug Development

Advanced Intelligent Discovery, EarlyView.
Wang et al. analyze 592 drug development studies published between 2020 and 2024 that applied design of experiments methodologies. The review surveys both classical and emerging approaches—including Bayesian optimization and active learning—and identifies a critical gap between advanced experimental strategies and their practical adoption in ...
Fanjin Wang, Anthony Harker, Mohan Edirisinghe, Maryam Parhizkar   +3 more
wiley   +1 more source

Magnetic Resonance Imaging of Optic Nerve Traction During Adduction in Primary Open-Angle Glaucoma With Normal Intraocular Pressure. [PDF]

, 2017
PurposeWe used magnetic resonance imaging (MRI) to ascertain effects of optic nerve (ON) traction in adduction, a phenomenon proposed as neuropathic in primary open-angle glaucoma (POAG).MethodsSeventeen patients with POAG and maximal IOP ≤ 20 mm Hg, and
Bonelli, Laura, Caprioli, Joseph, Clark, Robert A, Coleman, Anne L, Demer, Joseph L, Giaconi, JoAnn A, Law, Simon K, Nouri-Mahdavi, Kouros, Suh, Soh Youn   +8 more
core   +1 more source

The Herfindahl neutral point: A firm‐level threshold for managing market concentration with evidence from US hog packing

American Journal of Agricultural Economics, EarlyView.
Abstract This paper derives a firm‐level threshold, the Herfindahl Neutral Point, from the standard concentration index used in merger review. At this threshold, a marginal expansion leaves the index unchanged. Firms below the threshold reduce concentration when they expand; firms above it increase concentration.
Andrew J. Keller, Krishna P. Paudel
wiley   +1 more source

Quantitative assessment of relative peripheral refraction in children with different refractive statuses and its associations with ocular biometry

Frontiers in Medicine
BackgroundThis study aimed to evaluate the distribution of relative peripheral refraction (RPR) and its relationship with ocular biometry in Chinese children of different refractive statuses.MethodsThis study included 309 participants aged 4 to 14 years ...
Chaoying Ye, Chaoying Ye, Chaoying Ye, Xingxue Zhu, Xingxue Zhu, Xingxue Zhu, Yangfan Xu, Yangfan Xu, Yangfan Xu, Yuliang Wang, Yuliang Wang, Yuliang Wang, Yujia Liu, Yujia Liu, Yujia Liu, Jianmin Shang, Jianmin Shang, Jianmin Shang, Xiaomei Qu, Xiaomei Qu, Xiaomei Qu   +20 more
doaj   +1 more source

Posterior corneal surface stability after femtosecond laser-assisted keratomileusis [PDF]

, 2015
The purpose of this study was to evaluate posterior corneal surface variation after femtosecond laser-assisted keratomileusis in patients with myopia and myopic astigmatism. Patients were evaluated by corneal tomography preoperatively and at 1, 6, and 12
Cagini, Carlo, Fiore, Tito, Fruttini, Daniela, Lupidi, Marco, Messina, Marco, Piccinelli, Francesco, SPADEA, LEOPOLDO   +6 more
core   +3 more sources

Phenotype Expansion of Malan Syndrome: New Cases and a Review of the Literature

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Malan syndrome is an ultra‐rare overgrowth syndrome caused by pathogenic variants or deletions in nuclear factor one X (NFIX) located at 19p13.2. Here, we report a comprehensive literature review and phenotyping of known patients with Malan syndrome and present a novel cohort of eight patients.
Alex F. Nisbet, Sylvie A. Adams, Zoe S. Katz, Christal G. Delagrammatikas, Kosuke Izumi, Winifred Sigal, Kim Ventarola, Elaine H. Zackai, Julia E. Reid, Grant T. Liu, Jennifer M. Kalish   +10 more
wiley   +1 more source

Agreement between a new optical low coherence reflectometry biometer and an anterior segment optical coherence tomographer

Eye and Vision, 2023
Background To assess agreement of measurements between a new optical low coherence reflectometry (OLCR) biometer (SW-9000, Suoer, Tianjin, China) and a spectral-domain optical coherence tomographer (SD-OCT)/Placido topographer (MS-39, CSO, Florence ...
Yiran Wang, Ting Wan, Luze Liu, Yuyuan Xue, Xinyao Chen, Giacomo Savini, Domenico Schiano-Lomoriello, Xingtao Zhou, Jinjin Yu, Jinhai Huang   +9 more
doaj   +1 more source

Long‐Term Follow Up of Two Patients With Variants in the Cluster 1031‐1159 of TRRAP Gene: Expanding the Phenotype of Developmental Delay With or Without Dysmorphic Facies and Autism

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The transformation/transcription domain‐associated protein (TRRAP) gene encodes a large multidomain protein, a member of the phosphatidylinositol 3‐kinase‐related kinase (PIKK) family. TRRAP is a component of the histone acetyltransferase (HAT) complex, and it plays an important role in gene transcription, DNA repair, and cell‐cycle regulation.
Roseli Maria Zechi‐Ceide, Vinicius Contrucci Dantas Segarra, Siulan Vendramini‐Pittoli, Henrique Regonaschi Serigatto, Luiza Virmond, Heloisa Marcelina da Cunha Palhares, Fernanda Jehee, Ana Cristina Victorino Krepischi, Carla Rosenberg, Carlos Henrique Paiva Grangeiro, Nancy Mizue Kokitsu‐Nakata   +10 more
wiley   +1 more source

TGFBI Gene Mutation Analysis of Clinically Diagnosed Granular Corneal Dystrophy Patients Prior to PTK: A Pilot Study from Eastern China

Scientific Reports, 2017
This study investigated the TGFBI gene mutation types in outpatients clinically diagnosed with granular corneal dystrophy (GCD) prior to phototherapeutic keratectomy (PTK), also calculated the mutation rate of subjects with normal corneas, but positive ...
Li Zeng, Jing Zhao, Yingjun Chen, Feng Zhao, Meiyan Li, Connie Chao-Shern, Tara Moore, John Marshall, Xingtao Zhou   +8 more
doaj   +1 more source