Results 21 to 30 of about 134,424 (302)

Metabolic memory in mitochondrial oxidative damage triggers diabetic retinopathy

BMC Ophthalmology, 2018
Background Diabetic retinopathy (DR) is a microvascular complication induced by high blood glucose. This study was conducted to investigate the effect of metabolic memory on mitochondrial oxidative damage-induced DR. Methods Rat retinal endothelial cells
Zhaoge Wang, Haixia Zhao, Wenying Guan, Xin Kang, Xue Tai, Ying Shen   +5 more
doaj   +1 more source

Pre-treatment With Ranibizumab Aggravates PDT Injury and Alleviates Inflammatory Response in Choroid-Retinal Endothelial Cells

Frontiers in Cell and Developmental Biology, 2020
Polypoidal choroidal vasculopathy (PCV) is the predominant subtype of exudative age-related macular degeneration in Asians. Although photodynamic therapy (PDT) is widely used for PCV treatment, its long-term beneficial effects are unsatisfactory ...
Yang Liu, Yang Liu, Min Zhu, Min Zhu, Ruowen Gong, Ruowen Gong, Xin Wang, Xin Wang, Lei Li, Lei Li, Gezhi Xu, Gezhi Xu   +11 more
doaj   +1 more source

Myopes have significantly higher serum melatonin concentrations than non-myopes [PDF]

, 2017
Purpose Experimental animal models of myopia demonstrate that higher melatonin (Mel) and lower dopamine (DA) concentrations actively promote axial elongation.
Ackermann, Atkinson, Ayaki, Baba, Barnard, Beck-Friis, Benavente-Pérez, Benloucif, Berg, Bertolet, Besharse, Breslin, Brown, Cahill, Chang, Chiba, Chua, Delgado, Dong, Eisenberg, Fan, Freedman, Guo, Hammond, He, Hua, Huang, Huang, Hughes, Iuvone, Jee, Kivelä, Lanyon, Logan, Lu, Mallen, Mao, Martin, McCullough, Megaw, Megaw, Nickla, Nickla, Ohngemach, Panda, Pendrak, Rada, Rao, Riefahn, Rohrer, Rose, Rudnicka, Sankaridurg, Skene, Stone, Stone, Stormann, Tosini, Trier, Verkicharla, Wahl, Wallman, Wang, Weiss, Wiechmann, Wiechmann, Wilson, Witkovsky, Wu, Xu, Zhang   +70 more
core   +2 more sources

Defocus incorporated multiple segments (DIMS) spectacle lenses increase the choroidal thickness: a two-year randomized clinical trial

Eye and Vision, 2023
Background Myopia control interventions, such as defocus incorporated multiple segments (DIMS) spectacle lenses, have been adopted in school-aged children to reduce the prevalence of myopia and its complications.
Rachel Ka Man Chun, Hanyu Zhang, Zhengji Liu, Dennis Yan Yin Tse, Yongjin Zhou, Carly Siu Yin Lam, Chi Ho To   +6 more
doaj   +1 more source

Human PrimPol mutation associated with high myopia has a DNA replication defect [PDF]

, 2014
PrimPol is a primase-polymerase found in humans, and other eukaryotes, involved in bypassing lesions encountered during DNA replication. PrimPol employs both translesion synthesis and repriming mechanisms to facilitate lesion bypass by the replisome ...
Aguilera, Aidan J. Doherty, Benjamin A. Keen, Bianchi, Biertümpfel, Brissett, Brown, Donigan, Garcia-Gomez, Iyer, Jones, Keen, Laura J. Bailey, Li, Lobley, Morgan, Mourón, Nemec, Nemec, Pitcher, Rudd, Sale, Saw, Stanislaw K. Jozwiakowski, Vitale, Wan, Washington, Zhao   +27 more
core   +1 more source

Defocused Images Change Multineuronal Firing Patterns in the Mouse Retina

Cells, 2020
Myopia is a major public health problem, affecting one third of the population over 12 years old in the United States and more than 80% of people in Hong Kong. Myopia is attributable to elongation of the eyeball in response to defocused images that alter
Seema Banerjee, Qin Wang, Chung Him So, Feng Pan   +3 more
doaj   +1 more source

Ocular hypertension in myopia: analysis of contrast sensitivity [PDF]

, 2018
Purpose: we evaluated the evolution of contrast sensitivity reduction in patients affected by ocular hypertension and glaucoma, with low to moderate myopia.
Arrico, L, Bianchini, D, Migliorini, R, Nebbioso, M., Quercia, A   +4 more
core   +1 more source

Thirty-month results after the treatment of post-LASIK ectasia with allogenic lenticule addition and corneal cross-linking: a case report

BMC Ophthalmology, 2018
Background To report a first case of lenticule addition and corneal cross-linking for post-LASIK ectasia with associated corneal thinning. Case presentation Lenticule addition followed by corneal cross-linking was performed on the left eye of a patient ...
Meiyan Li, Dong Yang, Feng Zhao, Tian Han, Meng Li, Xingtao Zhou, Katherine Ni   +6 more
doaj   +1 more source

Conjunctival ultraviolet autofluorescence area, but not intensity, is associated with myopia [PDF]

, 2019
Background:Conjunctival ultraviolet autofluorescence (CUVAF) has been used as a biomarker of time spent outdoors and smaller CUVAF area is associated with myopia in Southern Hemisphere cohorts.
Healy, Martin, Kearney, Stephanie, Laird, Eamon, O'Donoghue, Lisa, Pourshahidi, Laura K, Richardson, Patrick, Saunders, Kathryn J   +6 more
core   +2 more sources

Size of living space as a moderator for central and peripheral refractions in children

Scientific Reports, 2023
Undesirable living environment may impose risk on myopia development. Furthermore, peripheral refractive error was suggested to contribute to juvenile eye growth modulation.
Kai Yip Choi, Tsz Wing Leung, Henry Ho-Lung Chan   +2 more
doaj   +1 more source