Results 111 to 120 of about 2,898,126 (296)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Experimental and numerical research on axial compression performance of precast concrete columns with a novel steel connection

Frontiers in Materials
To investigate the axial compression performances of precast concrete columns with a novel steel connection, axial compression tests were carried out on 14 specimens.
Jinlong Guo, Jinlong Guo, Chao Li, Chao Li, Min Chen, Min Chen, Yanfei Guo, Qiang Fu, Yongjin Li, Yongjin Li   +9 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Experimental Study on and Finite Element Analysis of the Axial Compression Bearing Capacity of a UHPC Transfer Device for Pre-Stressed Anti-Floating Anchor Rods

Buildings
A new UHPC pre-stress transfer device is proposed for pre-stressed anti-floating anchor rods. To investigate the axial compression performance of the device during pre-stressing, physical experiments and a finite element verification were conducted on ...
Yi Zhu, Yi Li, Zhen-Xing Tang, Pei-Lin Liu, Zhuo Yang   +4 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

The Transport Sector : A Laboratory for Good Practices in Capacity Development?

, 2006
As articulated in the Paris Declaration on Aid Effectiveness (2005), country capacity is at the core of sustainable development.
Davis, Deborah
core   +1 more source

Experimental study on the ultimate axial anti-slide capacity for a partially-embedded pipeline on the sloping sandy seabed

, 2015
The ultimate anti-slide capacity for a submarine pipeline on the sloping seabed is one of the main concerns in the global buckling design. A mechanical-actuator facility has been designed and constructed for physical modeling of the axial pipe-soil ...
Hu C(胡存), Gao FP(高福平), Wang N(汪宁)   +2 more
core   +2 more sources

Experimental and Numerical Investigation on the Ultimate Bearing Capacity of Axially Compressed Steel Tube Columns with Local Corrosion

Buildings
In this paper, 17 types of circular, hollow steel tube columns were designed for the axial compression test. A defect was corroded with an acid rain spray method.
Wei Fang, Tao Wang, Mengcheng Chen, Mingyang Zhang, Hong Huang, Kaicheng Xu, Qingqing Wen   +6 more
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Finite element analysis of high-rise prefabricated shear walls with discontinuous rebars

Scientific Reports
The seismic performance of vertical reinforcement discontinuous splice prefabricated shear walls (SGBL prefabricated shear walls) in high-rise buildings is investigated in this study.
Zhiqi Li, Jun Peng, Hairen Wang, Wenyi Xia, Jianyin Lei, Jiaxin He, Yunhui Chen, Yaoyao Liu, Jiahui Zhang, Xiyong Sun, Haiping Xie   +10 more
doaj   +1 more source