Results 101 to 110 of about 2,898,126 (296)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Elastic Behavior and Load-Carrying Capacity of Longitudinal Shuttle-Shaped Concrete-Filled Steel Column with Cruciform Sections

Buildings
Longitudinal shuttle-shaped concrete-filled steel column with cruciform sections (LSS-CFST-CS) is highly valued by architects and structural engineers for its distinctive appearance and significant architectural impact in spatial steel structures ...
Boli Zhu, Qiang Fu, Haoxiang Liao, Xiaodong Wang   +3 more
doaj   +1 more source

Orthogonal Analysis of Axial Bearing Capacity of Short Columns Reinforced by Circular Steel Tube and Ultra High Performance Concrete with Coarse Aggregate

Renmin Zhujiang, 2021
This paper analyzes the influence of outer diameter of steel tube, wall thickness of steel tube, steel strength and concrete strength on the axial bearing capacity of short columns reinforced by circular steel tube and ultra high performance concrete ...
TANG Jiajun, WANG Tan, LI Jiuyang
doaj  

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Illustrative Quotes, Interview Guide and Information Sheets for: Developing laboratory capacity for Good Laboratory Practice certification: lessons from a Tanzanian insecticide testing facility

Interview guide used across 5 test facilities in 3 African countries to explore enablers, barriers and effects of a research capacity strengthening programme, targeting development of a Quality Management System compliant with Good Laboratory Practice ...
Capacity Research, Centre for
core   +1 more source

Axial flux permanent magnet machines for direct drive applications [PDF]

, 2007
This thesis explores aspects of the design, analysis, and experimental test of permanent magnet axial flux machines for use in diesel engine generator sets, vertical axis wind turbines, and wheel motors for solar cars.
Martin, Richard
core  

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Strengthening research management support services in sub-Saharan African universities and research institutions - table 1: location, institution type, focal science, and number of participants interviewed in each capacity assessment

Table 1: Location, institution type, focal science and number of participants interviewed in each capacity ...
Centre for Capacity Research
core   +1 more source

Optimization of Artificial Intelligence System by Evolutionary Algorithm for Prediction of Axial Capacity of Rectangular Concrete Filled Steel Tubes under Compression. [PDF]

Materials (Basel), 2020
Nguyen HQ, Ly HB, Tran VQ, Nguyen TA, Le TT, Pham BT.   +5 more
europepmc   +1 more source