Results 41 to 50 of about 88,253 (267)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Development and mechanical properties of a locking T-plate

Pesquisa Veterinária Brasileira
: This study aimed to develop a locking T-plate and to evaluate its mechanical properties in synthetic models. A titanium 2.7mm T-plate was designed with a shaft containing three locked screw holes and one dynamic compression hole, and a head with two ...
Luciane R. Mesquita, Sheila C. Rahal, Camilo Mesquita Neto, Washington T. Kano, Antônio C. Beato, Luís G. Faria, Maíra S. Castilho   +6 more
doaj   +1 more source

Snaking and laddering in axially compressed cylinders

International Journal of Mechanical Sciences, 2021
Abstract Recent experimental and numerical results have illustrated the importance of spatially localised buckling modes in the loss of stability of axially compressed cylinders. Particular interest has focused on a single localised dimple that circumferentially multiplies along a post-critical equilibrium path of oscillating end-shortening—a ...
R.M.J. Groh, G.W. Hunt, A. Pirrera
openaire   +2 more sources

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Effect of the axial load on the dynamic response of the wrapped CFRP reinforced concrete column under the asymmetrical lateral impact load.

PLoS ONE, 2023
This study investigated the impact of axial load on the dynamic response of reinforced concrete (RC) members to asymmetrical lateral impact loads. A series of asymmetrical-span impact tests were conducted on circular and square RC members with and ...
Khalil Al-Bukhaiti, Liu Yanhui, Zhao Shichun, Hussein Abas, Han Daguang, Xu Nan, Yang Lang, Yan Xing Yu   +7 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Study on Creep Compression Characteristics of Pressure-Bearing Graded Crushed Rock

Buildings
To study the creep compression characteristics and evolution mechanism of pressure-bearing graded crushed rock under constant load. Creep compression tests of crushed rock were conducted using the self-developed confined compression test system under ...
Yu Tian, Mei Zhi, Jie Zhou, Pengfei Ji, Shitong Peng   +4 more
doaj   +1 more source

Femoral periprosthetic fracture treatment using the Ortho-Bridge System: a biomechanical study

Journal of Orthopaedic Surgery and Research, 2022
Background We undertook a comparative biomechanical study of type B1 fractures around femoral prostheses following cemented hip arthroplasty using the Ortho-Bridge System (OBS) and a locking compression plate/locking attachment plate structure (LCP + LAP)
Yuntao Long, Yubin Qi, Guilai Zuo, Qingjie Zhang, Zhenlin Liu, Wen Wang   +5 more
doaj   +1 more source