Results 41 to 50 of about 88,526 (267)

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Development and mechanical properties of a locking T-plate

Pesquisa Veterinária Brasileira
: This study aimed to develop a locking T-plate and to evaluate its mechanical properties in synthetic models. A titanium 2.7mm T-plate was designed with a shaft containing three locked screw holes and one dynamic compression hole, and a head with two ...
Luciane R. Mesquita, Sheila C. Rahal, Camilo Mesquita Neto, Washington T. Kano, Antônio C. Beato, Luís G. Faria, Maíra S. Castilho   +6 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Molecular Dynamics Modeling of the Effect of Axial and Transverse Compression on the Residual Tensile Properties of Ballistic Fiber

Fibers, 2017
Ballistic impact induces multiaxial loading on Kevlar® and polyethylene fibers used in protective armor systems. The influence of multiaxial loading on fiber failure is not well understood.
Sanjib C. Chowdhury, Subramani Sockalingam, John W. Gillespie   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Bearing capacity of UHPC-filled circular steel tube short column under axial compression

Građevinar
This study establishes a predictive formula for the axial compression bearing capacity of Ultra High Performance Concrete (UHPC) filled circular steel tube (circular UHPCFST) short columns. The basis for establishing this formula is the derivation method
Shengbing Fang
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Study on Strain Resistance Effect of Smart Concrete Under Triaxial Compression

工程科学与技术, 2013
:The strain resistance effect of smart concrete under triaxial compression was studied,and compared with the result measured under uniaxial compression.The results showed that during elastic stage of deformation,the axial resistance decreases with the ...
郑立霞, 李卓球, 宋显辉, 张小玉   +3 more
doaj  

Effect of the axial load on the dynamic response of the wrapped CFRP reinforced concrete column under the asymmetrical lateral impact load.

PLoS ONE, 2023
This study investigated the impact of axial load on the dynamic response of reinforced concrete (RC) members to asymmetrical lateral impact loads. A series of asymmetrical-span impact tests were conducted on circular and square RC members with and ...
Khalil Al-Bukhaiti, Liu Yanhui, Zhao Shichun, Hussein Abas, Han Daguang, Xu Nan, Yang Lang, Yan Xing Yu   +7 more
doaj   +1 more source