Results 71 to 80 of about 700,926 (305)

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

open access: yesFEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell   +2 more
wiley   +1 more source

GAS HOLDUP AND AXIAL LIQUID DISPERSION IN THREE PHASE BUBBLE COLUMNS

open access: yesJournal of Engineering and Sustainable Development, 2015
Axial liquid dispersion coefficient was studied in air-tap water systems (bubble columns) and air-tap water-PVC solid particles systems for different column diameters, 10, 15, and 30 cm, Each column had a gas distributor plate with perforated holes of
Burhan Sadeq Abdulrazzaq
doaj  

Axial Dispersion in Gas-Bubble Columns

open access: yesChemical engineering, 1971
本研究では前報の流動モデルの理論を拡張し, 循環速度分布の存在は平均流方向での混合となることに基づいて, Taylor, Ticha・cekらによって論じられた速度分布モデルを適用し, 気泡塔装置の乱流域における軸方向混合拡散についての理論式を導いた。この結果に対し, 前報で得られた実験式を導入して, 気泡塔への適用を試みた。総括の混合拡散係数を, 平均循環速度と塔径基準のPe数で表現し, また, 混合拡散に対するガス空塔速度と塔径の影響を示す相関式を導いた。
Shyu, Chia-San, Miyauchi, Terukatau
openaire   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Study the Axail Dispersion Model in Ion Exchange Column

open access: yesAl-Khawarizmi Engineering Journal, 2009
A mathematical model is developed which predicates the performance of cylindrical ion exchange bed involving comparing of axial dispersion model for cation exchange column with different assumption, this model permits the performance to predicate the ...
Iman Hahider Mahdi
doaj   +2 more sources

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

Residence time distribution and flow pattern modeling of oilseeds in a pilot screw press☆

open access: yesOilseeds and fats, crops and lipids, 2020
Mechanical expression is widely applied for oil recovery from oilseeds using continuous screw presses. Despite significant recent advances in the field of press design and automation, it remains difficult to predict the press performances based on the ...
Bogaert Laurine   +2 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

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