Results 131 to 140 of about 700,926 (305)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

open access: yesFEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer   +7 more
wiley   +1 more source

Experimental comparison between a counter-rotating axial-flow fan and a conventional rotor-stator stage [PDF]

open access: yes, 2013
Based on the requirement of energy consumption level and weight and dimension restriction, compact axial machines are highly demanded in many industrial fields.
BAKIR, Farid   +2 more
core  

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

open access: yesFEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong   +3 more
wiley   +1 more source

Axial Spondyloarthritis

open access: yes, 2016
Axial spondyloarthritis is the commonest inflammatory arthritis affecting the spine. Typically first presenting to a variety of primary and secondary care professionals, the high global disease burden of this condition has created a need for increased ...

core  

Development of a test-rig for exploring optimal conditions of small unmanned aerial vehicle co-axial rotor systems

open access: yes, 2010
Due to the recent increase in development and use of co-axial rotor system at the scale of small UAVs a greater understanding of the performance variables that affect the co-axial propulsion system at low Reynolds number operation has become increasingly
Brazinskas, Mantas   +4 more
core   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

open access: yesFEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin   +3 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

open access: yesFEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour   +2 more
wiley   +1 more source

Solute dispersion in a permeable capillary with wall exchange: Darcy flow model [PDF]

open access: yes
Complex chemical reactions and hydrodynamic dispersion feature in many aspects of hemodynamics. Motivated by examining the reactive phase change dispersion in perfusion, a mathematical study is presented for solute dispersion in incompressible laminar ...
Shaw, Sachin   +4 more
core  

Home - About - Disclaimer - Privacy