Results 51 to 60 of about 661 (214)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

Cone mosaic in eyes with varied axial length using adaptive optics scanning laser ophthalmoscopy

open access: yesPhotodiagnosis and Photodynamic Therapy
Background: Abnormalities in cone photoreceptor topography are closely associated with the development of various ocular diseases, including axial myopia.
Wen-Da Zhou   +11 more
doaj   +1 more source

The behavior of the electric field in X and O modes in traveling wave tubes filled with magnetized plasma

open access: yesResults in Physics, 2016
In this article magnetized plasma filled traveling wave tubes are investigated. The mentioned system, is located inside a cylindrical wall. The space between the helix and the wall is filled with dielectric material.
M. Shaban, A. Baharvand, S. Saviz
doaj   +1 more source

Fabrication and analysis of mechanical properties of PVC/Glass fiber/graphene nano composite pipes

open access: yesMaterials Research Express, 2020
The aim of this work is to examine the conventional moulding method for manufacturing the PVC/Glass fiber/graphene nano composites. Uniform graphene dispersion is observed with the matrix for better bonding.
G Shanmugasundar   +6 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Liquid-Phase Back mixing in Bubble Columns

open access: yesTikrit Journal of Engineering Sciences, 2013
Liquid-phase axial dispersion coefficients have been measured for air-water system in bubble columns of 10, 15 and 30 cm diameter. The experiments are carried out using a transient method (the tracer response method).
Burhan S. Abdulrazak
doaj  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Guided Waves in a Solid Rod Embedded in Infinite Medium with Weak Interface

open access: yesMATEC Web of Conferences, 2016
The dispersion relation of the infinite long rod model with a weak interface has been deduced via wave equation of the guided waves and boundary spring interface model.
Tong Zi Wei   +5 more
doaj   +1 more source

Effects of Temperature and Axial Strain on Four-Wave Mixing Parametric Frequencies in Microstructured Optical Fibers Pumped in the Normal Dispersion Regime

open access: yesPhotonics, 2014
A study of the effect of temperature and axial strain on the parametric wavelengths produced by four-wave mixing in microstructured optical fibers is presented. Degenerate four-wave mixing was generated in the fibers by pumping at normal dispersion, near
Javier Abreu-Afonso   +3 more
doaj   +1 more source

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