Results 51 to 60 of about 12,329 (259)
Analysis and Modeling of Non-Spherical Particle Motion in a Gas Flow
KONA Powder and Particle Journal, 2022 This paper describes the reviews of the recent works in analysis, modeling, and simulation of the motion of a non-spherical particle. The motion of the non-spherical particles was analyzed in detail by means of a fully resolved direct numerical ...
Hiroaki Watanabe, Wei Zhang
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Investigation of Factors Influencing Dispersion of Liquid Hydrocarbons in Porous Media
Journal of Engineering, 2016 An experimental work has been done to study the major factors that affect the axial dispersion of some hydrocarbons during liquid-liquid miscible displacement.
Hussain Ali Baker
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Liquid-Phase Back mixing in Bubble Columns
Tikrit Journal of Engineering Sciences, 2013 Liquid-phase axial dispersion coefficients have been measured for air-water system in bubble columns of 10, 15 and 30 cm diameter. The experiments are carried out using a transient method (the tracer response method).
Burhan S. Abdulrazak
doaj
Axial dispersion of the liquid phase in a three-phase Karr reciprocating plate column [PDF]
Journal of the Serbian Chemical Society, 2004 The influence of the gas flow rate and vibration intensity in the presence of the solid phase (polypropylene spheres) on axial mixing of the liquid phase in a three phase (gas-liquid-solid) Karr reciprocating plate column (RPC) was investigated. Assuming
DEJAN U. SKALA +4 more
doaj
Fluids, 2017 The effective medium approach to radial fixed bed dispersion models, in which radial dispersion of mass is superimposed on axial plug flow, is based on a constant effective dispersion coefficient, DT.
Anthony G. Dixon, Nicholas J. Medeiros
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source