Results 51 to 60 of about 12,991 (254)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
GAS HOLDUP AND AXIAL LIQUID DISPERSION IN THREE PHASE BUBBLE COLUMNS
Journal of Engineering and Sustainable Development, 2015 Axial liquid dispersion coefficient was studied in air-tap water systems (bubble columns) and air-tap water-PVC solid particles systems for different column diameters, 10, 15, and 30 cm, Each column had a gas distributor plate with perforated holes of
Burhan Sadeq Abdulrazzaq
doaj
Experimental investigation of axial dispersion in a horizontal rotating cylinder [PDF]
, 2021 This work reports experimental measurements of the dispersion of particles during rotation in a horizontal cylinder. The axial dispersion of a pulse of approximately monodisperse black glass ballotini into a bed of clear glass ballotini of the same size ...
Müller, C., Third, J., McLaren, C.
core
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Hydrodynamics of a pilot plant spray extraction column [PDF]
Acta Periodica Technologica, 2018 The hydrodynamic characteristics of the liquid-liquid system of toluene-water in a pilot plant spray extraction column were experimentally determined.
Sovilj Milan N. +2 more
doaj +1 more source
Analysis and Modeling of Non-Spherical Particle Motion in a Gas Flow
KONA Powder and Particle Journal, 2022 This paper describes the reviews of the recent works in analysis, modeling, and simulation of the motion of a non-spherical particle. The motion of the non-spherical particles was analyzed in detail by means of a fully resolved direct numerical ...
Hiroaki Watanabe, Wei Zhang
doaj +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Axial dispersion characteristics in three-phase fluidized beds
, 1992 The effects of liquid and gas velocities, liquid viscosity and surface tension, particle size and column diameter on the axial dispersion coefficients (D(Z)) of liquid phase in three-phase fluidized beds have been determined in two large (0.254 and 0.376
Kim, Sang Done +5 more
core +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source