Results 61 to 70 of about 1,963,356 (295)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Analysis and Modeling of Non-Spherical Particle Motion in a Gas Flow

KONA Powder and Particle Journal, 2022
This paper describes the reviews of the recent works in analysis, modeling, and simulation of the motion of a non-spherical particle. The motion of the non-spherical particles was analyzed in detail by means of a fully resolved direct numerical ...
Hiroaki Watanabe, Wei Zhang
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Determining axial dispersion coefficients of pilot-scale annular pulsed disc and doughnut columns

Chinese Journal of Chemical Engineering, 2020
Abstract In this study, a computational fluid dynamics (CFD) method was adopted to calculate axial dispersion coefficients of annular pulsed disc and doughnut columns (APDDCs). Passive tracer was uniformly injected by pulse input at the continuous phase inlet, and its concentration governing equation was solved in liquid–liquidtwo-phase flow fields ...
Xiong Yu, Han Zhou, Qiang Zheng, Shan Jing, Wenjie Lan, Shaowei Li   +5 more
openaire   +1 more source

Experimental investigation of axial dispersion in a horizontal rotating cylinder [PDF]

, 2021
This work reports experimental measurements of the dispersion of particles during rotation in a horizontal cylinder. The axial dispersion of a pulse of approximately monodisperse black glass ballotini into a bed of clear glass ballotini of the same size ...
Müller, C., Third, J., McLaren, C.
core  

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Investigation of Factors Influencing Dispersion of Liquid Hydrocarbons in Porous Media

Journal of Engineering, 2016
An experimental work has been done to study the major factors that affect the axial dispersion of some hydrocarbons during liquid-liquid miscible displacement.
Hussain Ali Baker, Lecturer
doaj   +2 more sources

Measurement of the axial dispersion coefficient of powders in a rotating cylinder: dependence on bulk flow properties [PDF]

Powder Technology, 2016
Abstract Rotating drums are encountered in numerous industrial applications, including blenders, rotary calciners, impregnators, coaters, granulators, and cement mixers. In all of these devices, the rotation of the drum is used to engender mixing of the granular material in the radial direction.
Sara Koynov, Yifan Wang, Agnesa Redere, Prashani Amin, Heather N. Emady, Fernando J. Muzzio, Benjamin J. Glasser   +6 more
openaire   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source