Results 41 to 50 of about 1,553,042 (294)

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

Dynamic studies of nitrophenols sorption on perfil in a fixed-bed column

open access: yesMacedonian Journal of Chemistry and Chemical Engineering, 2008
The adsorption of two substituted nitrophenols, namely 4-nitrophenol (4-NP) and 2,4-dinitrophenol (2,4-DNP), from aqueous solutions onto perfil was studied using a fixed bed column.
Zvezdelina Yaneva   +4 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Measurement of Axial Dispersion Coefficient of the Continuous Phase in a Pulsed Disc and Doughnut Column Using Dispersion Model with Radiotracer Technique [PDF]

open access: yesمجله علوم و فنون هسته‌ای, 2016
High efficiency and low required area for the pulsed columns are interesting and useful especially in nuclear industries in spite of exposure and radiation protection requirements.
M Tabasi   +3 more
doaj  

Axial dispersion model in predictive mass transfer correlation for random pulsed packed column [PDF]

open access: yesChemical Industry and Chemical Engineering Quarterly, 2015
The continuous phase volumetric overall mass transfer coefficient in a ceramic intalox saddle pulsed packed extraction column using axial dispersion model was studied for two different liquid-liquid systems containing water/acetone/toluene and ...
Teflanab R.   +3 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

Thermal Modelling of the Ventilation and Cooling inside Axial Flux Permanent Magnet Generators [PDF]

open access: yes, 2010
Axial flux permanent magnet generators are of particular interest for power generation in harsh and confined conditions. Due to their compactness and high power density, the ventilation and cooling inside axial flux permanent magnet generators have ...
LIM, CHIN,HONG, Lim, Chin Hong
core  

Oscillatory flow and axial dispersion in packed beds of spheres

open access: yes, 2005
The effect of oscillations in the bulk flow on the axial dispersion coefficient in packed beds of spherical particles has been studied using the imperfect pulse tracer method with two probes located within the bed.
Lau, A   +3 more
core   +1 more source

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