Results 71 to 80 of about 885,795 (303)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Influence of design parameters on the global performances of low-speed counter-rotating axial-flow fans [PDF]
, 2014 The present work aims at experimentally investigating the effects of some parameters on the performances of a counter-rotating stage, and on the instationary flow between the rotors.
BAKIR, Farid +5 more
core +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
CES Transactions on Electrical Machines and Systems, 2018 In order to accurately analyze the magnetic field of conical-rotor permanent magnet synchronous motor (CR-PMSM), the effectiveness of two methods was studied on handling of problems concerned with non-uniform distribution of magnetic field along axial ...
Jiabao Wang +3 more
doaj +1 more source
Instrumentation and axial load testing of displacement piles
Proceedings of the Institution of Civil Engineers - Geotechnical Engineering, 2014 Despite the fact that results of many instrumented pile load tests have been reported in the literature, it is difficult to find well-documented instrumentation procedures that can be used when planning a load testing programme. A load test programme designed to investigate various aspects of the design and behaviour of driven steel piles is discussed ...
Bica, Adriano V.D. +4 more
openaire +2 more sources
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Finite elements for modeling of localized failure in reinforced concrete [PDF]
, 2013 In this work, several beam finite element formulations are proposed for failure analysis of planar reinforced concrete beams and frames under monotonic static loading.
Jukić, Miha
core
The axial behaviour of displacement piles in chalk
, 2018 Current axial capacity design methods for piles driven in chalk are known to be unreliable, in particular where low-medium density material is encountered. The primary complexities associated with using driven pre-formed displacement piles to withstand predominantly axial loading include (i) determining their installation resistance (ii) assessing pile
openaire +2 more sources
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
GEM-TN-94-607 A Simple Technique for Measuring
, 2007 A method is described for determining axial displacement along a stretched wire by driving both ends of a resistive wire as a bi-directional voltage divider and measuring the local signal balance with a capacitive pickup.
Gem Motivation +2 more
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