Results 61 to 70 of about 7,931,210 (255)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Electroosmotic Pressure-Driven Flow through a Slit Micro-Channel with Electric and Magnetic Transverse Field

Journal of Applied Fluid Mechanics, 2019
In the present study, flow through two-dimensional microchannel under an axial electric field, transverse electric and magnetic fields and with axial pressure gradient has been investigated numerically.
A. Moradmand, M. Saghafian, B. Moghimi Mofrad   +2 more
doaj  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

COMPARATIVE ANALYSIS OF ACTIVE POWER LOSSES OF INDUCTION MOTORS WITH CYLINDRICAL AND AXIAL AIR GAPS

Electrical engineering & Electromechanics, 2015
Purpose. To find the analytical expressions of determining the optimum geometric dimensions by criteria of the losses minimum of axial field squirrel-cage induction motors and to compare traditional and axial field motors. Methodology.
А.А. Stavinskii, О.О. Palchykov
doaj  

Hybrid fluid-kinetic cylindrical equilibria with axial background magnetic field

Fundamental Plasma Physics
Self-consistent, one-dimensional quasineutral screw-pinch equilibria are constructed within a hybrid model that couples fluid electrons with kinetic ions governed by the Vlasov equation. The equilibria depend on the radial coordinate perpendicular to the
D.A. Kaltsas, A.I. Kuiroukidis, G.N. Throumoulopoulos   +2 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Field model of coreless axial flux machines [PDF]

, 2010
A very interesting construction of disc-type machines are coreless machines. Because there is no core in the stator this type of axial flux machines doesn't have a cogging torque, iron losses or eddy current.
Król, E., Glinka, T., Wolnik, T.
core  

Development of a Performance-Based Design Technique for an Axial-Flow Fan Unit Using Airfoil Cascades Based on the Blade Strip Theory

Applied Sciences
Axial-flow fans are widely used as cooling fans in the outdoor units of split-type air conditioners. The design of an axial-flow fan blade involves stacking several airfoils that can be differently designed for each spanwise section. However, the complex
Seo-Yoon Ryu, Cheolung Cheong, Jong Wook Kim, Byung Il Park   +3 more
doaj   +1 more source

Diffraction-limited axial double foci and optical traps generated by optimization-free planar lens

Nanophotonics, 2020
Axial diffraction-limited multiple foci are a kind of investigated focal field for trapping multiple nano-particles. We first experimentally generated diffraction-limited axial double foci by optimization-free binary planar lens and theoretically ...
Ma Long, Guan Jian, Wang Yiqun, Chen Chen, Zhang Jianlong, Lin Jie, Tan Jiubin, Jin Peng   +7 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source