Results 151 to 160 of about 736 (213)

Human‐Scale Rotating Magnetic Field Delivery With Permanent Magnets Under Anatomic and Robotic Constraints

open access: yesAdvanced Robotics Research, EarlyView.
Rotating magnetic fields (RMFs) are widely used for microrobot propulsion and control. We show that RMF generation with permanent magnets is mechanically feasible for many limb and intracranial applications but becomes constrained for thoracic targets.
Tuan‐Anh Le   +4 more
wiley   +1 more source

Perivascular Matrix Densification Dysregulates Angiogenesis and Activates Pro‐Inflammatory Endothelial Cells

open access: yesAdvanced Science, EarlyView.
Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia   +17 more
wiley   +1 more source

Intravital Multimodal Imaging of Human Cortical Organoid Transplantation in a Mouse Model of Chronic Stroke

open access: yesAdvanced Science, EarlyView.
A multimodal intravital imaging platform enables longitudinal tracking of human cortical organoids transplanted into chronic stroke lesions. By combining surgical microscopy, MRI, bioluminescence imaging, and two‐photon fluorescence microscopy, the platform captures graft placement, viability dynamics, and cellular‐scale morphology in vivo, offering a ...
Jinghui Wang   +12 more
wiley   +1 more source

Agnuside Stabilizes the Complex I Assembly Factor NDUFAF6 to Reinforce Mitochondrial Efficiency and Thermogenic Responsiveness

open access: yesAdvanced Science, EarlyView.
ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao   +7 more
wiley   +1 more source

Cross Kingdom Metabolic Engineering Paradigm Elevating Sustainable Protein Production

open access: yesAdvanced Science, EarlyView.
ABSTRACT Confronting the dual crisis of escalating global protein demand and unsustainable agriculture necessitates transformative solutions. Here, we pioneer evolutionary insights from maize nitrogen optimization via asparagine synthetase (ASNS) to rewire metabolism in Pichia pastoris.
Yuanyuan Du   +4 more
wiley   +1 more source

Controller for an Axial Flow Blood Pump

Artificial Organs, 1996
Abstract: A rotary blood pump inherently provides only one noninvasive “observable‘” parameter (motor current) and allows for only one “controllable” parameter (pump speed). To maintain the systemic circulation properly, the pump speed must be controlled to sustain appropriate outlet Hows and perfusion pressure while preventing pulmonary damage caused
H, Konishi   +11 more
openaire   +3 more sources

Axial Flow Catheter Pump for Circulatory Support

Biomedizinische Technik/Biomedical Engineering, 2002
The development of a percutaneously insertable catheter pump for temporary left ventricular and circulatory support in patients with acute ischemic cardiomyopathy.The expandable axial flow pump (introduction diameter 9-F, expanded diameter 6.5 mm) is mounted at the tip of a catheter, designed to be placed in aortic transvalvular position.
T, Schmitz-Rode   +6 more
openaire   +2 more sources

Advanced Suction Detection for an Axial Flow Pump

Artificial Organs, 2006
Abstract:  An automatic detection system for ventricular collapse was developed and tested in a first clinical trial as part of a physiological speed control concept for axial flow pumps. From this clinical experience, and based on the acquired data during this trial, an optimization of the developed system was performed.
Michael, Vollkron   +5 more
openaire   +2 more sources

Development of an Axial Flow Blood Pump LVAS

ASAIO Journal, 1992
Nimbus, Inc., (Rancho Cordova, CA) and the University of Pittsburgh (Pittsburgh, PA) are collaborating to develop an implantable rotary blood pump that can be used as a left ventricular assist system (LVAS). The short-term goal of this project is to show that an LVAS based on this pump can operate safely and reliably during chronic implantations in ...
K C, Butler   +8 more
openaire   +2 more sources

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