Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells
FEBS Open Bio, EarlyView.Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla +10 more
wiley +1 more source
FEBS Open Bio, EarlyView.TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao +10 more
wiley +1 more source
Multilayer Impedance Pump: A Bio-Inspired Valveless Pump with Medical Applications [PDF]
, 2007 This thesis introduces the concept of multilayer impedance pump, a novel pumping mechanism inspired from the embryonic heart structure. The multilayer impedance pump is a composite two-layer fluid-filled elastic tube featuring a thick, gelatin-like ...
Loumes, Laurence
core +1 more source
Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach +23 more
wiley +1 more source
UNSTEADY VELOCITY PIV MEASUREMENTS AND 3D NUMERICAL CALCULATION COMPATISONS INSIDE THE IMPELLER OF A RADIAL PUMP MODEL [PDF]
, 2013 PIV measurements were performed at mid hub section inside the impeller of a vaned diffuser pump model working with air. Several previous papers have already presented part of impeller flow characteristics mainly for vaneless diffuser and near nominal ...
PAVESI, Giorgio +5 more
core
INDIRECT METHODS OF MEASURING FLОW RATE AND PRESSURE DROP OF ROTARY BLOOD PUMPS
Вестник трансплантологии и искусственных органов, 2015 The article describes complex software to calculate the main parameters of the axial pump (pressure drop and flow rate) on the basis of an analysis of its technical characteristics (current consumption and pump speed).
G. P. Itkin +3 more
doaj +1 more source
White Matter and Perivascular Imaging Changes in Alzheimer's Disease and Cerebral Amyloid Angiopathy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Peak‐width of skeletonized mean diffusivity (PSMD) and diffusion tensor imaging–analysis along the perivascular space (DTI‐ALPS), reflecting white matter integrity and glymphatic function, are altered in Alzheimer's disease (AD).
Debina Laishram +3 more
wiley +1 more source
Numerical study of the influence of Geometrical Parameters on flow in water Pump-Sump [PDF]
, 2009 Water for irrigation, domestic and industrial supply as well for some power generation is normally drawn directly from rivers or from reservoir through sumps.
BOIS, Gérard +2 more
core
Investigating the temporal-spatial evolution mechanism of axial forces in centrifugal pump impellers under varying operating conditions using dynamic mode decomposition [PDF]
AIP AdvancesThe centrifugal pump is an important component of pumped storage power stations, but the axial force on the impeller significantly affects their stability.
Jiaming Xu +3 more
doaj +1 more source
The Gut–Heart Axis in Systemic Sclerosis: Evidence From a Large Prospective Early Disease Cohort
Arthritis Care &Research, EarlyView.Objective Cardiac involvement significantly impacts prognosis in systemic sclerosis (SSc), highlighting the need for early risk stratification. Gastrointestinal (GI) symptoms are common and often manifest early. Emerging data suggest a link between GI and cardiac manifestations, possibly through shared mechanisms like dysautonomia.
Francesca R. Di Ciommo +9 more
wiley +1 more source