Results 41 to 50 of about 1,050,413 (300)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Engineering Science and Technology, an International Journal, 2017 Higher efficiency is always a desire for the electric machines researchers. One serious candidate is the axial flux permanent magnet motor to achieve that. These machines have advantages on power and torque density profile. This study aims to analyse the
Emrah Cetin, Ferhat Daldaban
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Thermal Modelling of the Ventilation and Cooling inside Axial Flux Permanent Magnet Generators [PDF]
, 2010 Axial flux permanent magnet generators are of particular interest for power generation in harsh and confined conditions. Due to their compactness and high power density, the ventilation and cooling inside axial flux permanent magnet generators have ...
LIM, CHIN,HONG, Lim, Chin Hong
core
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Iranian Journal of Electrical and Electronic Engineering, 2020 Optimization of specific power of axial flux permanent magnet brushless DC (PMBLDC) motor based on genetic algorithm optimization technique for an electric vehicle application is presented.
A. N. Patel, B. N. Suthar
doaj
Power Electronics and Drives, 2019 The paper presents the possibility of using neural networks in the detection of stator and rotor electrical faults of induction motors. Fault detection and identification are based on the analysis of symptoms obtained from the fast Fourier transform of ...
Ewert Paweł
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
IEEE AccessAxial flux permanent magnet synchronous motors are promising for urban air mobility propulsion because of their high-power density and compact structure.
Seunghwan Lee +6 more
doaj +1 more source