Results 131 to 140 of about 257,175 (322)

Resistance and Elastic Stiffness of RHS "T" Joints: Part II - Combined Axial Brace and Chord Loading

Latin American Journal of Solids and Structures
This paper deals with the behaviour of welded "T" joints between RHS sections submitted to tension brace loading combined with chord axial loading.
R.M.M.P. de Matos, L.F. Costa-Neves, L.R.O. de Lima, P.C.G.S. Vellasco, J.G.S. da Silva   +4 more
doaj   +1 more source

Experimental and numerical analysis of the cyclic behaviour of RC beam-column connections with plain reinforcing bars [PDF]

, 2012
The information available in the literature about the cyclic behaviour of reinforced concrete elements with plain reinforcing bars is scarce. As a consequence, the influence of bar slippage in elements with plain bars is not yet comprehensively ...
Costa, A., Fernandes, C., Melo, J., Varum, H.   +3 more
core   +1 more source

Adoption of integrated cattle and oil palm farming system in Malaysia [PDF]

, 2020
Malaysian government had encouraged the adoption of integrated cattle and oil palm farming system (ICOFS) since the year 1998. This is due to large areas of land suitable for ICOFS in Malaysia that can be well utilised. Rising up the participation in
Mohd Nasir, Aini Syafiqah
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

New Gasostatic Borehole Bearings - Construction and Research [PDF]

, 2016
In the article the origin of creation, construction as well as the research of the novel gasostatic borehole bearings are presented. In the first part of the paper the information on the construction of the bearing is outlined whereas in the second part ...
Kawczyński, Sławomir, Oryński, Franciszek, Pawłowski, Witold   +2 more
core  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Strut-tie method of design and possible serviceability problems: an exploration by NLFE [PDF]

, 2000
The strut and tie method presents a rational and consistent approach to the design of all parts in a reinforced concrete structure. With this approach, the load carrying mechanism of the structure is represented by approximating the compressive stress
Bhatt, P., Cunningham, L.S.
core  

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source