Results 121 to 130 of about 257,175 (322)
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Behavior of axial thrust caused by intake sump vortices in a vertical mixed flow pump
Nihon Kikai Gakkai ronbunshu, 2017 Axial thrust forces acting on an impeller of a diffuser type mixed flow pump and the behavior of the axial thrust generated by the vortex occurrence in a pump intake sump were studied.
Yuji KANEMORI, Yasuo HANDA
doaj +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Biomechanical restoration in unilateral facet arthroplasty: a cadaveric evaluation
North American Spine Society Journal: Background: Facet incompetency can lead to altered spine biomechanics. However, while total posterior arthroplasty techniques in lieu of fusion are of increasing interest, unilateral techniques are yet to be investigated.
Christopher D. Sturm, MD +4 more
doaj +1 more source
Electromechanical Reliability Testing of Three-Axial Silicon Force Sensors [PDF]
, 2006 This paper reports on the systematic electromechanical characterization of a new three-axial force sensor used in dimensional metrology of micro components. The siliconbased sensor system consists of piezoresistive mechanicalstress transducers integrated
Bartholomeyczik, J. +8 more
core +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Failure behaviour of preloaded API line pipe threaded connections [PDF]
, 2011 This paper reports on numerical and experimental work concerning the fatigue behaviour and sealing capacity of threaded pipe connections (1” API Line Pipe). Numerical simulations are performed using Abaqus® in combination with ThreadGen©.
De Baets, Patrick +5 more
core +1 more source
, 2013 In this paper, the effect of local defects, viz., cracks and cutouts on the buckling behaviour of functionally graded material plates subjected to mechanical and thermal load is numerically studied.
Chakraborty, S +3 more
core +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source